Interrelationship among Obstructive Sleep Apnea, Renal Function and Survival: A Cohort Study

Patrizia Pochetti, Danila Azzolina, Beatrice Ragnoli, Paolo Amedeo Tillio, Vincenzo Cantaluppi and Mario Malerba
Additional contact information
Patrizia Pochetti: Respiratory Unit, Sant’ Andrea Hospital, 13100 Vercelli, Italy
Danila Azzolina: Department of Traslational Medicine, University of Eastern Piedmont, 28100 Novara, Italy
Beatrice Ragnoli: Respiratory Unit, Sant’ Andrea Hospital, 13100 Vercelli, Italy
Paolo Amedeo Tillio: Respiratory Unit, Sant’ Andrea Hospital, 13100 Vercelli, Italy
Vincenzo Cantaluppi: Department of Traslational Medicine, Nephrology and Kidney Transplant Unit, University of Eastern Piedmont, 28100 Novara, Italy
Mario Malerba: Respiratory Unit, Sant’ Andrea Hospital, 13100 Vercelli, Italy

IJERPH, 2020, vol. 17, issue 14, 1-12

Abstract: Previous studies showed a bidirectional relationship between renal function decline and obstructive sleep apnea (OSA) syndrome. Continuous Positive Airway Pressure (C-PAP) treatment was shown to preserve the kidney function in OSA patients. This study aims to investigate the progression of long-term renal function in OSA patients treated with different PAP strategies (patients were divided into two groups, fixed C-PAP or other PAP—automatic and bilevel pressure). Comorbidities and 10-years survival were also evaluated. We performed a retrospective, observational, single-center, cohort study, including the first 40 consecutive patients enrolled from 2009 in the Respiratory disease Unit at the Vercelli University Hospital database. The patient inclusion criteria were: age ≥ 18 years with OSA syndrome according to AASM (American Academy of Sleep Medicine) guidelines. Creatinine serum levels (mg/dL) and the estimated Glomerular Filtration Rate (eGFR, mL/min calculated by CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration equation)) were measured at 3 different time points: at baseline, 3 years and 8 years after PAP treatment. The Kaplan–Meier survival curves stratified according to PAP treatment and compliance have been reported together with log-rank test estimation. In our study, we found a significant creatinine serum level reduction after 3 years of fixed C-PAP treatment ( p value = 0.006) when compared to baseline values. However, we observed that the long-term C-PAP benefit was not significant ( p value = 0.060). Our data confirmed the progressive renal function decline in OSA patients, especially in those using other-PAP treatments; nevertheless, OSA treatment with a fixed C-PAP device has shown, in the short term, a significant improvement in renal function. By contrast, in our study, long-term benefits after 8 years are not been demonstrated probably because of the lack of compliance of the patients and the aging effect.

Keywords: obstructive sleep apnea; C-PAP; creatinine; eGFR (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.mdpi.com/1660-4601/17/14/4922/pdf (application/pdf)
https://www.mdpi.com/1660-4601/17/14/4922/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:17:y:2020:i:14:p:4922-:d:381852

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().