Association between the Genetic Variants of Glutathione Peroxidase 4 and Severity of Endometriosis

Yun-Yao Huang, Cheng-Hsuan Wu, Chung-Hsien Liu, Shun-Fa Yang, Po-Hui Wang, Long-Yao Lin, Tsung-Hsien Lee and Maw-Sheng Lee
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Yun-Yao Huang: Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung 40203, Taiwan
Cheng-Hsuan Wu: Women’s Health Research Laboratory, Changhua Christian Hospital, Changhua 50006, Taiwan
Chung-Hsien Liu: Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung 40203, Taiwan
Shun-Fa Yang: Institute of Medicine, Chung Shan Medical University, Taichung 40203, Taiwan
Po-Hui Wang: Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung 40203, Taiwan
Long-Yao Lin: Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung 40203, Taiwan
Tsung-Hsien Lee: Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung 40203, Taiwan
Maw-Sheng Lee: Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung 40203, Taiwan

IJERPH, 2020, vol. 17, issue 14, 1-9

Abstract: It has been reported that oxidative and nitrative stress might be the pathogenesis of endometriosis. This prospective case-control study attempted to check the connection between single nucleotide polymorphism (SNP) of three antioxidant enzymes (glutathione peroxidase 4 (GPX4), thioredoxin 2 (TXN2), thioredoxin reductase 1 (TXNRD1)) and endometriosis. We recruited 90 patients with histology-approved endometriosis as the case group and 130 age-matched women for an annual pap smear examination as the control group. The stage of endometriosis was evaluated with revised ASRM score. Both groups were genotyped in the peripheral leukocytes for the SNP of GPX4 (rs713041), TXN2 (rs4821494) and TXNRD1 (rs1128446) by PCR-based methods. An X 2 test was used to analysis of the difference of allele frequency and SNP distribution between two groups. The results revealed GPX4 (rs713041) has a significantly different distribution between two groups (C:T = 116 (44.6%):144 (55.4%) in control and C:T = 104 (57.8%): 76 (42.2%) in endometriosis groups, p = 0.007). The SNP in TXN2 (rs4821494) also showed a difference in allele frequency (G:T = 180 (69.2%):80 (30.8%) in control and G:T = 141 (78.3%):39 (21.6%) in endometriosis group, p = 0.030). In addition, the SNP GPX4 (rs713041) was associated with the severity of the endometriosis. Women who have advanced stage endometriosis were different from mild endometriosis in genetic variants of GPX4 gene ( p = 0.001). In conclusion, the relationship between endometriosis and SNP of antioxidant enzymes, GPX4 and TXN2, was confirmed by the present study. According to the result, we suggested that the GPX4 might contribute to the pathogenesis of endometriosis.

Keywords: single nucleotide polymorphism; oxidative stress; endometriosis; glutathione peroxidase; thioredoxin; thioredoxin reductase (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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