Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study

Yolanda Benavente, Laura Costas, Marta Maria Rodríguez-Suarez, Juan Alguacil, Miguel Santibáñez, Javier Vila, Claudia Robles, Esther Alonso, Esmeralda de la Banda, Eva Gonzalez-Barca, Trinidad Dierssen-Sotos, Eva Gimeno Vazquez, Marta Aymerich, Elias Campo, José J. Jiménez-Moleón, Rafael Marcos-Gragera, Gemma Castaño-Vinyals, Nuria Aragonés, Marina Pollan, Silvia de Sanjose, Manolis Kogevinas, Adonina Tardón and Delphine Casabonne
Additional contact information
Yolanda Benavente: Cancer Epidemiology Research Programme, Institut Català d’Oncologia (IDIBELL), L’Hospitalet de Llobregat, 08908 Barcelona, Spain
Laura Costas: Cancer Epidemiology Research Programme, Institut Català d’Oncologia (IDIBELL), L’Hospitalet de Llobregat, 08908 Barcelona, Spain
Marta Maria Rodríguez-Suarez: Public Health Department, University of Oviedo, 33011 Oviedo, Spain
Juan Alguacil: Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
Miguel Santibáñez: Faculty of Nursing, University of Cantabria—IDIVAL, 39008 Santander, Spain
Javier Vila: Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
Claudia Robles: Cancer Epidemiology Research Programme, Institut Català d’Oncologia (IDIBELL), L’Hospitalet de Llobregat, 08908 Barcelona, Spain
Esther Alonso: Department of Pathology, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, 08908 Barcelona, Spain
Esmeralda de la Banda: Department of Pathology, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, 08908 Barcelona, Spain
Eva Gonzalez-Barca: Hematology, Institut Català d’ Oncologia (IDIBELL), Universitat de Barcelona, L’ Hospitalet de Llobregat, 08908 Barcelona, Spain
Trinidad Dierssen-Sotos: Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
Eva Gimeno Vazquez: Hematology, Hospital del Mar, 08003 Barcelona, Spain
Marta Aymerich: Hematopathology Unit/Hemato-Oncology Department, Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), 08001 Barcelona, Spain
Elias Campo: Hematopathology Unit/Hemato-Oncology Department, Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), 08001 Barcelona, Spain
José J. Jiménez-Moleón: Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
Rafael Marcos-Gragera: Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
Gemma Castaño-Vinyals: Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
Nuria Aragonés: Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
Marina Pollan: Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
Silvia de Sanjose: Cancer Epidemiology Research Programme, Institut Català d’Oncologia (IDIBELL), L’Hospitalet de Llobregat, 08908 Barcelona, Spain
Manolis Kogevinas: Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
Adonina Tardón: Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
Delphine Casabonne: Cancer Epidemiology Research Programme, Institut Català d’Oncologia (IDIBELL), L’Hospitalet de Llobregat, 08908 Barcelona, Spain

IJERPH, 2020, vol. 17, issue 14, 1-11

Abstract: We aimed to study the association between occupational exposure to pesticides and chronic lymphocytic leukemia (CLL) in Spain. Occupational exposure to pesticides (four insecticides, four herbicides and two fungicides) was evaluated using a job-exposure matrix for the Spanish population (MatEmESp) among 302 CLL cases and 1567 population controls in five regions of Spain, 2010–2013. Cumulative exposure scores (CES) were obtained by summing across the exposed jobs the product of prevalence, intensity and duration of exposure to each active substance. Principal components analysis (PCA) and logistic regression models adjusted for age, sex, region, education and occupational exposure to solvents were used. Around 20% of controls and 29% of cases were exposed to one or more pesticides. Compared to non-exposed, subjects in the highest tertile (3rd tertile) of CES of insecticides, herbicides, fungicides were more likely to have CLL [OR (95% CI), P-trend; 2.10 (1.38; 3.19), 0.002; 1.77 (1.12; 2.80), 0.12; and 1.67 (1.06; 2.64), 0.10, respectively). Following PCA, the first component (PC1, explaining 70% of the variation) equally led by seven active substances (the insecticide pyrethrin, all herbicides, all fungicides) was associated with a 26% higher odds of having CLL for 1-standard deviation increase in PC1 (95% CI: 1.14 to 1.40). These results confirm previous associations between CLL and exposure to pesticides and provide additional evidence by application groups and active substance. However, more research is needed to disentangle independent effects of individual active substances.

Keywords: pesticides; job-exposure matrix; chronic lymphocytic leukemia; occupational exposure (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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