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Effectiveness of Internet- and Mobile-Based Cognitive Behavioral Therapy to Reduce Suicidal Ideation and Behaviors: Protocol for a Systematic Review and Meta-Analysis of Individual Participant Data

Rebekka Büscher, Marie Beisemann, Philipp Doebler, Lena Steubl, Matthias Domhardt, Pim Cuijpers, Ad Kerkhof and Lasse B. Sander
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Rebekka Büscher: Department of Rehabilitation Psychology and Psychotherapy, Albert-Ludwigs-University of Freiburg, 79106 Freiburg, Germany
Marie Beisemann: Department of Statistics, TU Dortmund University, 44227 Dortmund, Germany
Philipp Doebler: Department of Statistics, TU Dortmund University, 44227 Dortmund, Germany
Lena Steubl: Department of Clinical Psychology and Psychotherapy, Ulm University, 89069 Ulm, Germany
Matthias Domhardt: Department of Clinical Psychology and Psychotherapy, Ulm University, 89069 Ulm, Germany
Pim Cuijpers: Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, 1081 BT Amsterdam, The Netherlands
Ad Kerkhof: Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, 1081 BT Amsterdam, The Netherlands
Lasse B. Sander: Department of Rehabilitation Psychology and Psychotherapy, Albert-Ludwigs-University of Freiburg, 79106 Freiburg, Germany

IJERPH, 2020, vol. 17, issue 14, 1-11

Abstract: Internet- and mobile-based cognitive behavioral therapy (iCBT) might reduce suicidal ideation. However, recent meta-analyses found small effect sizes, and it remains unclear whether specific subgroups of participants experience beneficial or harmful effects. This is the study protocol for an individual participant meta-analysis (IPD-MA) aiming to determine the effectiveness of iCBT on suicidal ideation and identify moderators. We will systematically search CENTRAL, PsycINFO, Embase, and Pubmed for randomized controlled trials examining guided or self-guided iCBT for suicidality. All types of control conditions are eligible. Participants experiencing suicidal ideation will be included irrespective of age, diagnoses, or co-interventions. We will conduct a one-stage IPD-MA with suicidal ideation as the primary outcome, using a continuous measure, reliable improvement and deterioration, and response rate. Moderator analyses will be performed on participant-, study-, and intervention-level. Two independent reviewers will assess risk of bias and the quality of evidence using Cochrane’s Risk of Bias Tool 2 and GRADE. This review was registered with OSF and is currently in progress. The IPD-MA will provide effect estimates while considering covariates and will offer novel insights into differential effects on a participant level. This will help to develop more effective, safe, and tailored digital treatment options for suicidal individuals.

Keywords: individual participant data meta-analysis; review; suicidal ideation; suicide; internet-based; mobile-based; online; cognitive behavioral therapy; iCBT (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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