Analysis of Benzene Exposure in Gas Station Workers Using Trans,Trans-Muconic Acid

Barbara Rodrigues Geraldino, Rafaella Ferreira Nascimento Nunes, Juliana Barroso Gomes, Isabela Giardini, Paula Vieira Baptista da Silva, Élida Campos, Katia Soares da Poça, Rocio Hassan, Ubirani Barros Otero and Marcia Sarpa
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Barbara Rodrigues Geraldino: Technical Area of Environment, Work and Cancer, Prevention and Surveillance Coordination, National Cancer Institute José Alencar Gomes da Silva–INCA, Rio de Janeiro CEP 20230-240, Brazil
Rafaella Ferreira Nascimento Nunes: Technical Area of Environment, Work and Cancer, Prevention and Surveillance Coordination, National Cancer Institute José Alencar Gomes da Silva–INCA, Rio de Janeiro CEP 20230-240, Brazil
Juliana Barroso Gomes: Technical Area of Environment, Work and Cancer, Prevention and Surveillance Coordination, National Cancer Institute José Alencar Gomes da Silva–INCA, Rio de Janeiro CEP 20230-240, Brazil
Isabela Giardini: Technical Area of Environment, Work and Cancer, Prevention and Surveillance Coordination, National Cancer Institute José Alencar Gomes da Silva–INCA, Rio de Janeiro CEP 20230-240, Brazil
Paula Vieira Baptista da Silva: Technical Area of Environment, Work and Cancer, Prevention and Surveillance Coordination, National Cancer Institute José Alencar Gomes da Silva–INCA, Rio de Janeiro CEP 20230-240, Brazil
Élida Campos: Technical Area of Environment, Work and Cancer, Prevention and Surveillance Coordination, National Cancer Institute José Alencar Gomes da Silva–INCA, Rio de Janeiro CEP 20230-240, Brazil
Katia Soares da Poça: Technical Area of Environment, Work and Cancer, Prevention and Surveillance Coordination, National Cancer Institute José Alencar Gomes da Silva–INCA, Rio de Janeiro CEP 20230-240, Brazil
Rocio Hassan: Oncovirology Laboratory, Bone Marrow Transplantation Center (CEMO), National Cancer Institute José Alencar Gomes da Silva–INCA, Rio de Janeiro CEP 20230-130, Brazil
Ubirani Barros Otero: Technical Area of Environment, Work and Cancer, Prevention and Surveillance Coordination, National Cancer Institute José Alencar Gomes da Silva–INCA, Rio de Janeiro CEP 20230-240, Brazil
Marcia Sarpa: Technical Area of Environment, Work and Cancer, Prevention and Surveillance Coordination, National Cancer Institute José Alencar Gomes da Silva–INCA, Rio de Janeiro CEP 20230-240, Brazil

IJERPH, 2020, vol. 17, issue 15, 1-13

Abstract: In Brazil, gas station workers are occupationally exposed to the benzene present in gasoline. Brazilian law indicates the use of trans,trans-muconic acid(t,t-MA) as a biomarker of benzene exposure. The aim of this study was to evaluate the level of exposure to benzene in gas station workers, through the quantification of t,t-MA present in urine. A total number of 269 gas station workers divided into 179 filling station attendants exposed by inhalation and dermal route and 90 convenience store workers exposed only by inhalation were included. A control group was formed by 100 office workers, without occupational exposure to benzene. The urinary levels of t,t-MA were evaluated by HPLC with a UV detector. Gas station workers showed higher mean values of t,t-MA (0.204 mg/g creatinine; 95% CI 0.170–0.237) than office workers (0.126 mg/g creatinine; 95% CI 0.0817–0.1693). T,t-MA levels were higher in convenience store workers exposed to gasoline only by inhalation (0.221 mg/g creatinine; 95% CI 0.160–0.282), than in those exposed to gasoline by inhalation and dermal route—filling station attendants (0.195 mg/g creatinine; 95% CI 0.155–0.235). Gas station workers with a higher level of t,t-MA had epistaxis. T,t-MA values were higher in the Downtown (0.15 mg/g creatinine) region’s workers than in the more affluent South Zone region’s workers (0.07 mg/g creatinine). Smoking habits influenced the urinary t,t-MA values, while the frequency of consumption of industrialized and frozen foods showed no influence.

Keywords: benzene; gas station workers; t,t-MA (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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