Coffee Consumption, Genetic Polymorphisms, and the Risk of Type 2 Diabetes Mellitus: A Pooled Analysis of Four Prospective Cohort Studies

An Na Kim, Hyun Jeong Cho, Jiyoung Youn, Taiyue Jin, Moonil Kang, Joohon Sung and Jung Eun Lee
Additional contact information
An Na Kim: Department of Food and Nutrition, Seoul National University, Seoul 08826, Korea
Hyun Jeong Cho: Department of Food and Nutrition, Seoul National University, Seoul 08826, Korea
Jiyoung Youn: Department of Food and Nutrition, Seoul National University, Seoul 08826, Korea
Taiyue Jin: Department of Food and Nutrition, Seoul National University, Seoul 08826, Korea
Moonil Kang: Institute of Health and Environment, Graduate School of Public Health, Seoul National University, Seoul 08826, Korea
Joohon Sung: Department of Epidemiology, School of Public Health, Seoul National University, Seoul 08826, Korea
Jung Eun Lee: Department of Food and Nutrition, Seoul National University, Seoul 08826, Korea

IJERPH, 2020, vol. 17, issue 15, 1-18

Abstract: The association between coffee consumption and the risk of type 2 diabetes may vary by genetic variants. Our study addresses the question of whether the incidence of type 2 diabetes is related to the consumption of coffee and whether this relationship is modified by polymorphisms related to type 2 diabetes. We performed a pooled analysis of four Korean prospective studies that included 71,527 participants; median follow-up periods ranged between 2 and 13 years. All participants had completed a validated food-frequency questionnaire (FFQ) at baseline. The odds ratios (ORs) and 95% confidence intervals (CIs) for type 2 diabetes were calculated using logistic regression models. The ORs were combined using a fixed or random effects model depending on the heterogeneity across the studies. Compared with 0 to <0.5 cups/day of coffee consumption, the OR for type 2 diabetes was 0.89 (95% CI: 0.80–0.98, p for trend = 0.01) for ≥3 cups/day of coffee consumption. We did not observe significant interactions by five single nucleotide polymorphisms (SNPs) related to type 2 diabetes ( CDKAL1 rs7756992, CDKN2A /B rs10811661, KCNJ11 rs5215, KCNQ1 rs163184, and PEPD rs3786897) in the association between coffee and the risk of type 2 diabetes. We found that coffee consumption was inversely associated with the risk of type 2 diabetes.

Keywords: coffee; type 2 diabetes mellitus; genetic polymorphism; pooled analysis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.mdpi.com/1660-4601/17/15/5379/pdf (application/pdf)
https://www.mdpi.com/1660-4601/17/15/5379/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:17:y:2020:i:15:p:5379-:d:390049

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().