Urinary Biomarkers of Exposure to Volatile Organic Compounds from the Population Assessment of Tobacco and Health Study Wave 1 (2013–2014)

Víctor R. De Jesús, Deepak Bhandari, Luyu Zhang, Christopher Reese, Kimberly Capella, Denise Tevis, Wanzhe Zhu, Arseima Y. Del Valle-Pinero, Guy Lagaud, Joanne T. Chang, Dana van Bemmel, Heather L. Kimmel, Eva Sharma, Maciej L. Goniewicz, Andrew Hyland and Benjamin C. Blount
Additional contact information
Víctor R. De Jesús: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control & Prevention, Atlanta, GA 30341, USA
Deepak Bhandari: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control & Prevention, Atlanta, GA 30341, USA
Luyu Zhang: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control & Prevention, Atlanta, GA 30341, USA
Christopher Reese: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control & Prevention, Atlanta, GA 30341, USA
Kimberly Capella: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control & Prevention, Atlanta, GA 30341, USA
Denise Tevis: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control & Prevention, Atlanta, GA 30341, USA
Wanzhe Zhu: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control & Prevention, Atlanta, GA 30341, USA
Arseima Y. Del Valle-Pinero: Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA
Guy Lagaud: Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA
Joanne T. Chang: Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA
Dana van Bemmel: Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA
Heather L. Kimmel: National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA
Eva Sharma: Westat, 1600 Research Boulevard, Rockville, MD 20850, USA
Maciej L. Goniewicz: Division of Cancer Prevention and Population Sciences, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USA
Andrew Hyland: Division of Cancer Prevention and Population Sciences, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USA
Benjamin C. Blount: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control & Prevention, Atlanta, GA 30341, USA

IJERPH, 2020, vol. 17, issue 15, 1-12

Abstract: Volatile organic compounds (VOCs) are ubiquitous in the environment. In the United States (U.S.), tobacco smoke is the major non-occupational source of exposure to many harmful VOCs. Exposure to VOCs can be assessed by measuring their urinary metabolites (VOCMs). The Population Assessment of Tobacco and Health (PATH) Study is a U.S. national longitudinal study of tobacco use in the adult and youth civilian non-institutionalized population. We measured 20 VOCMs in urine specimens from a subsample of adults in Wave 1 (W1) (2013–2014) to characterize VOC exposures among tobacco product users and non-users. We calculated weighted geometric means (GMs) and percentiles of each VOCM for exclusive combustible product users (smokers), exclusive electronic cigarette (e-cigarette) users, exclusive smokeless product users, and tobacco product never users. We produced linear regression models for six VOCMs with sex, age, race, and tobacco user group as predictor variables. Creatinine-ratioed levels of VOCMs from exposure to acrolein, crotonaldehyde, isoprene, acrylonitrile, and 1,3-butadiene were significantly higher in smokers than in never users. Small differences of VOCM levels among exclusive e-cigarette users and smokeless users were observed when compared to never users. Smokers showed higher VOCM concentrations than e-cigarette, smokeless, and never users. Urinary VOC metabolites are useful biomarkers of exposure to harmful VOCs.

Keywords: volatile organic compound metabolites; PATH Study; tobacco smoke exposure; e-cigarette users; smokeless tobacco users (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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