Low-Intensity Exercise Training Additionally Increases Mitochondrial Dynamics Caused by High-Fat Diet (HFD) but Has No Additional Effect on Mitochondrial Biogenesis in Fast-Twitch Muscle by HFD

Yun Seok Kang, Donghun Seong, Jae Cheol Kim and Sang Hyun Kim
Additional contact information
Yun Seok Kang: Department of Sports Science, College of Natural Science, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si 54896, Korea
Donghun Seong: Department of Sports Science, College of Natural Science, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si 54896, Korea
Jae Cheol Kim: Department of Sports Science, College of Natural Science, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si 54896, Korea
Sang Hyun Kim: Department of Sports Science, College of Natural Science, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si 54896, Korea

IJERPH, 2020, vol. 17, issue 15, 1-13

Abstract: This study examines how the high-fat diet (HFD) affects mitochondrial dynamics and biogenesis, and also whether combining it with low-intensity endurance exercise adds to these effects. Six 8-week-old male Sprague–Dawley (SD) rats were put on control (CON; standard chow diet), HF (HFD intake), and HFEx (HFD + low-intensity treadmill exercise) for 6 weeks. As a result, no change in body weight was observed among the groups. However, epididymal fat mass increased significantly in the two groups that had been given HFD. Blood free fatty acid (FFA) also increased significantly in the HF group. While HFD increased insulin resistance (IR), this was improved significantly in the HFEx group. HFD also significantly increased mitochondrial biogenesis-related factors (PPARδ, PGC-1α, and mtTFA) and mitochondrial electron transport chain proteins; however, no additional effect from exercise was observed. Mitochondrial dynamic-related factors were also affected: Mfn2 increased significantly in the HFEx group, while Drp1 and Fis-1 increased significantly in both the HF and HFEx groups. The number of mitochondria in the subsarcolemmal region, and their size in the subsarcolemmal and intermyofibrillar regions, also increased significantly in the HFEx group. Taken overall, these results show that HFD in combination with low-intensity endurance exercise has no additive effect on mitochondrial biogenesis, although it does have such an effect on mitochondrial dynamics by improving IR.

Keywords: high-fat diet; exercise; mitochondrial function; mitochondrial dynamics; mitochondrial biogenesis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/17/15/5461/pdf (application/pdf)
https://www.mdpi.com/1660-4601/17/15/5461/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:17:y:2020:i:15:p:5461-:d:391466

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().