Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS)

Yukiko Nishihama, Shoji F. Nakayama, Takahiro Tabuchi, Tomohiko Isobe, Chau-Ren Jung, Miyuki Iwai-Shimada, Yayoi Kobayashi, Takehiro Michikawa, Makiko Sekiyama, Yu Taniguchi, Hiroshi Nitta, Shin Yamazaki and on behalf of the Japan Environment and Children’s Study Group
Additional contact information
Yukiko Nishihama: Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan
Shoji F. Nakayama: Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan
Takahiro Tabuchi: Cancer Control Center, Osaka International Cancer Institute, Osaka 541-8567, Japan
Tomohiko Isobe: Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan
Chau-Ren Jung: Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan
Miyuki Iwai-Shimada: Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan
Yayoi Kobayashi: Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan
Takehiro Michikawa: Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan
Makiko Sekiyama: Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan
Yu Taniguchi: Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan
Hiroshi Nitta: Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan
Shin Yamazaki: Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan
on behalf of the Japan Environment and Children’s Study Group: Membership of the Japan Environment and Children’s Study Group is provided in the Acknowledgments.

IJERPH, 2020, vol. 17, issue 15, 1-13

Abstract: Few studies have assessed the accuracy of self-reported questionnaires to determine smoking habits relative to urinary biomarkers. This study investigated urinary cotinine cut-off concentrations distinguishing active, passive and non-smokers among pregnant women who participated in the Japan Environment and Children’s Study, a nationwide birth cohort study. Pregnant participants with measured urinary cotinine concentrations (UCCs) and who completed self-reported questionnaires on smoking status were included ( n = 89,895). The cut-off values (COVs) for active and passive smokers were calculated by fitting mixed normal distribution functions to UCCs. The sensitivity and specificity of the questionnaires were subsequently evaluated. The median (interquartile range) UCC was 0.24 (0.083–0.96) µg/g-creatinine, with the detection rate of 89%. The COV for distinguishing active smokers from passive and non-smokers was 36.8 µg/g-creatinine. When this COV was considered to represent the true condition, the questionnaire had a sensitivity of 0.523, a specificity of 0.998, a positive predictive value (PPV) of 0.967 and a negative predictive value (NPV) of 0.957. The COV for distinguishing passive smokers from non-smokers was 0.31 µg/g-creatinine, with the questionnaire having a sensitivity of 0.222, a specificity of 0.977, a PPV of 0.868 and an NPV of 0.644. As many as 78% of passive smokers might be misclassified as non-smokers.

Keywords: cotinine; pregnant women; cut-off value (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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