FGFR4 Gene Polymorphism Reduces the Risk of Distant Metastasis in Lung Adenocarcinoma in Taiwan

Ju-Pi Li, Hsien-Cheng Huang, Po-Jen Yang, Chien-Yuan Chang, Yu-Hua Chao, Thomas Chang-Yao Tsao, Hsuan Huang, Yu-Ching Hung, Ming-Ju Hsieh and Shun-Fa Yang
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Ju-Pi Li: School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Hsien-Cheng Huang: Department of Emergency Medicine, Kuang Tien General Hospital, Taichung 433, Taiwan
Po-Jen Yang: School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Chien-Yuan Chang: Petite Doris Clinic, Taichung 408, Taiwan
Yu-Hua Chao: School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Thomas Chang-Yao Tsao: School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Hsuan Huang: School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan
Yu-Ching Hung: School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan
Ming-Ju Hsieh: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Shun-Fa Yang: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan

IJERPH, 2020, vol. 17, issue 16, 1-11

Abstract: Fibroblast growth factor receptor 4 ( FGFR4) is involved in multiple physiological and pathological processes. Several genetic variants of FGFR4 have been shown to be associated with tumor progression in many cancers. However, its association, such as genetic variants and expression levels, with lung cancer is controversial. The present study examined the relationship between four single-nucleotide polymorphisms (SNPs; rs2011077 T/C, rs351855 G/A, rs7708357 G/A, and rs1966265 A/G) of FGFR4 and the risk of lung adenocarcinoma with the epidermal growth factor receptor ( EGFR ) mutation status in a Taiwanese cohort. The results demonstrated that FGFR4 rs2011077 (odds ratio (OR) = 0.348, 95% confidence interval (CI) = 0.136–0.891, p = 0.024), and rs351855 (OR = 0.296, 95% CI = 0.116–0.751, p = 0.008) showed an inverse association with distant metastasis in wild-type EGFR lung adenocarcinoma. Furthermore, a database analysis using The Cancer Genome Atlas revealed that the higher FGFR4 expression level was correlated with poor survival rates in wild-type EGFR lung adenocarcinoma. In conclusion, the data suggest that FGFR4 SNPs may help in identifying patient subgroups at low-risk for tumor metastasis, among carriers of lung adenocarcinoma bearing wild-type EGFR .

Keywords: lung cancer; FGFR4; polymorphism; EGFR mutation (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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