Associations of Preconception Exposure to Air Pollution and Greenness with Offspring Asthma and Hay Fever

Ingrid Nordeide Kuiper, Iana Markevych, Simone Accordini, Randi J. Bertelsen, Lennart Bråbäck, Jesper Heile Christensen, Bertil Forsberg, Thomas Halvorsen, Joachim Heinrich, Ole Hertel, Gerard Hoek, Mathias Holm, Kees de Hoogh, Christer Janson, Andrei Malinovschi, Alessandro Marcon, Torben Sigsgaard, Cecilie Svanes and Ane Johannessen
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Ingrid Nordeide Kuiper: Department of Occupational Medicine, Haukeland University Hospital, 5020 Bergen, Norway
Iana Markevych: Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, Ludwig Maximilian University of Munich, 85764 Munich, Germany
Simone Accordini: Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy
Randi J. Bertelsen: Department of Clinical Science, University of Bergen, 5020 Bergen, Norway
Lennart Bråbäck: Section of Sustainable Health, Department of Public Health and Clinical Medicine, Umea University, 901 87 Umea, Sweden
Jesper Heile Christensen: Department of Environmental Science, Aarhus University, 4000 Roskilde, Denmark
Bertil Forsberg: Section of Sustainable Health, Department of Public Health and Clinical Medicine, Umea University, 901 87 Umea, Sweden
Thomas Halvorsen: Department of Clinical Science, University of Bergen, 5020 Bergen, Norway
Joachim Heinrich: Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, Ludwig Maximilian University of Munich, 85764 Munich, Germany
Ole Hertel: Department of Environmental Science, Aarhus University, 4000 Roskilde, Denmark
Gerard Hoek: Institute for Risk Assessment Sciences, Utrecht University, 3584 CS Utrecht, The Netherlands
Mathias Holm: Department of Occupational and Environmental Medicine, University of Gothenburg, SE-405 30 Gothenburg, Sweden
Kees de Hoogh: Swiss Tropical and Public Health Institute, 4051 Basel, Switzerland
Christer Janson: Department of Medical Sciences, Respiratory, Allergy & Sleep Research, Uppsala University, 751 85 Uppsala, Sweden
Andrei Malinovschi: Department of Medical Sciences, Clinical Physiology, Uppsala University, 751 85 Uppsala, Sweden
Alessandro Marcon: Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy
Torben Sigsgaard: Section of Environment, Occupation & Health, Institute of Public Health, Aarhus University, 8000 Aarhus, Denmark
Cecilie Svanes: Department of Occupational Medicine, Haukeland University Hospital, 5020 Bergen, Norway
Ane Johannessen: Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, 5020 Bergen, Norway

IJERPH, 2020, vol. 17, issue 16, 1-14

Abstract: We investigated if greenness and air pollution exposure in parents’ childhood affect offspring asthma and hay fever, and if effects were mediated through parental asthma, pregnancy greenness/pollution exposure, and offspring exposure. We analysed 1106 parents with 1949 offspring (mean age 35 and 6) from the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study. Mean particulate matter (PM 2.5 and PM 10 ), nitrogen dioxide (NO 2 ), black carbon (BC), ozone (O 3 ) (µg/m 3 ) and greenness (normalized difference vegetation index (NDVI)) were calculated for parents 0–18 years old and offspring 0–10 years old, and were categorised in tertiles. We performed logistic regression and mediation analyses for two-pollutant models (clustered by family and centre, stratified by parental lines, and adjusted for grandparental asthma and education). Maternal medium PM 2.5 and PM 10 exposure was associated with higher offspring asthma risk (odds ratio (OR) 2.23, 95%CI 1.32–3.78, OR 2.27, 95%CI 1.36–3.80), and paternal high BC exposure with lower asthma risk (OR 0.31, 95%CI 0.11–0.87). Hay fever risk increased for offspring of fathers with medium O 3 exposure (OR 4.15, 95%CI 1.28–13.50) and mothers with high PM 10 exposure (OR 2.66, 95%CI 1.19–5.91). The effect of maternal PM 10 exposure on offspring asthma was direct, while for hay fever, it was mediated through exposures in pregnancy and offspring’s own exposures. Paternal O 3 exposure had a direct effect on offspring hay fever. To conclude, parental exposure to air pollution appears to influence the risk of asthma and allergies in future offspring.

Keywords: air pollution; greenness; preconception exposure; childhood asthma; childhood hay fever (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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