High-Sensitivity C-Reactive Protein Elevation Is Independently Associated with Subclinical Renal Impairment in the Middle-Aged and Elderly Population—A Community-Based Study in Northern Taiwan

Hai-Hua Chuang, Rong-Ho Lin, Wen-Cheng Li, Wei-Chung Yeh, Yen-An Lin and Jau-Yuan Chen
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Hai-Hua Chuang: Department of Family Medicine, Chang-Gung Memorial Hospital, Taipei & Linkou Branch, Taoyuan 33305, Taiwan
Rong-Ho Lin: Department of Industrial Engineering and Management, National Taipei University of Technology, Taipei 10608, Taiwan
Wen-Cheng Li: Department of Family Medicine, Chang-Gung Memorial Hospital, Taipei & Linkou Branch, Taoyuan 33305, Taiwan
Wei-Chung Yeh: Department of Family Medicine, Chang-Gung Memorial Hospital, Taipei & Linkou Branch, Taoyuan 33305, Taiwan
Yen-An Lin: Department of Family Medicine, Chang-Gung Memorial Hospital, Taipei & Linkou Branch, Taoyuan 33305, Taiwan
Jau-Yuan Chen: Department of Family Medicine, Chang-Gung Memorial Hospital, Taipei & Linkou Branch, Taoyuan 33305, Taiwan

IJERPH, 2020, vol. 17, issue 16, 1-10

Abstract: This cross-sectional study aimed to investigate the associations between high-sensitivity C-reactive protein (hs-CRP) and renal impairment (RI) among middle-aged and elderly people. We collected and analyzed demographic, anthropometric, metabolic, and renal function data in a community-based population in Northern Taiwan. We excluded subjects with acute inflammation from this study and defined RI as the presence of urinary albumin–creatinine ratio 30–300 mg/g or an estimated glomerular filtration rate of <60 mL/min/1.73 m 2 . There were 131, 125, and 125 participants in the low (≤0.80 mg/L), middle (0.81–1.76 mg/L), and high (>1.77 mg/L) hs-CRP tertiles, respectively. hs-CRP exhibited significantly positive correlations with body mass index, waist circumference, systolic blood pressure, triglyceride, and fasting plasma glucose, and a negative correlation with high-density lipoprotein. The prevalence and odds ratio of RI significantly increased across hs-CRP tertiles from low to high, and this trend remained significant after adjusting for the conventional cardiometabolic risk factors. hs-CRP ≥ 1.61 mg/L in the total group and ≥2.03 mg/L in the elderly group accurately predicted RI ( p = 0.01 and 0.03, respectively). These findings suggest that we should carefully evaluate the renal function for at-risk individuals with hs-CRP elevation.

Keywords: cardiometabolic risk factors; chronic kidney disease; community medicine; high-sensitivity C-reactive protein; renal impairment (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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Citations: View citations in EconPapers (1)

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