The Protective Effect of Xanthohumol on the Content of Selected Elements in the Bone Tissue for Exposed Japanese Quails to TCDD

Aleksandra Całkosińska, Marzena Dominiak, Sylwia Sobolewska, Anna Leśków, Małgorzata Tarnowska, Aleksander Całkosiński and Maciej Dobrzyński
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Aleksandra Całkosińska: Department of Oral Surgery, Wroclaw Medical University, Krakowska 26 Street, 50-425 Wroclaw, Poland
Marzena Dominiak: Department of Oral Surgery, Wroclaw Medical University, Krakowska 26 Street, 50-425 Wroclaw, Poland
Sylwia Sobolewska: Department of Animal Nutrition and Feed Management, Wroclaw University of Environmental and Life Sciences, Chelmonskiego 38c Street, 51-630 Wroclaw, Poland
Anna Leśków: Department of Nervous System Diseases, Faculty of Health Science, Wroclaw Medical University, Bartla Street 5, 51-618 Wroclaw, Poland
Małgorzata Tarnowska: Department of Nervous System Diseases, Faculty of Health Science, Wroclaw Medical University, Bartla Street 5, 51-618 Wroclaw, Poland
Aleksander Całkosiński: Students’ Scientific Association of Biomaterials and Experimental Dentistry, Wroclaw Medical University, Bujwida 44 Street, 50-368 Wroclaw, Poland
Maciej Dobrzyński: Department of Conservative Dentistry and Pedodontics, Wroclaw Medical University, Krakowska 26 Street, 50-425 Wroclaw, Poland

IJERPH, 2020, vol. 17, issue 16, 1-15

Abstract: Dioxins (including 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) are highly toxic and persistent chemicals widely distributed in the environment in trace amounts, and are side products of industrial and chemical processes. Exposure to dioxins leads to multiorgan morphological and functional abnormalities, including within the bone tissue, disrupting its microarchitecture and mechanical properties. Xanthohumol (XN) is a chemical compound classified as a prenylated flavonoid, distinguished by multidirectional biological action. The aim of the study is to assess whether xanthohumol, as a substance with strong antioxidant and anti-inflammatory properties, has the ability to eliminate the negative effects of TCDD on bone tissue. The experiment was conducted on adult Japanese quails. Two different doses of TCDD and xanthohumol were administered to birds. After euthanasia of animals, the research material in the form of cranial vault and hind limb bone was collected, and their mineral compositions of calcium, phosphorus, magnesium, zinc, and iron concentrations were determined using atomic emission spectrometry in an acetylene-air flame method. Our results indicate that the administration of TCDD at a low dose causes more dynamic changes in the concentration of elements in bone, in comparison to a higher dose of dioxin. Results show also that higher doses of the XN cause the linear increase in the concentration of phosphorus and iron in the bone of the hind limb, and calcium in the bones of the cranial vault. In conclusion, our experiment shows that the use of TCDD and XN in Japanese quails together in various doses influences the content of phosphorus, magnesium, zinc, and iron in the research material.

Keywords: TCDD; dioxins; antioxidants; xanthohumol; bone mineral composition; bone mineralization (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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