Predictors of Survival in Women with High-Risk Endometrial Cancer and Comparisons of Sandwich versus Concurrent Adjuvant Chemotherapy and Radiotherapy

Hui-Hua Chen, Wan-Hua Ting, Hsu-Dong Sun, Ming-Chow Wei, Ho-Hsiung Lin and Sheng-Mou Hsiao
Additional contact information
Hui-Hua Chen: Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao, New Taipei 220409, Taiwan
Wan-Hua Ting: Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao, New Taipei 220409, Taiwan
Hsu-Dong Sun: Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao, New Taipei 220409, Taiwan
Ming-Chow Wei: Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao, New Taipei 220409, Taiwan
Ho-Hsiung Lin: Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao, New Taipei 220409, Taiwan
Sheng-Mou Hsiao: Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao, New Taipei 220409, Taiwan

IJERPH, 2020, vol. 17, issue 16, 1-15

Abstract: Background: to elucidate the predictors of progression-free survival (PFS) and overall survival (OS) in high-risk endometrial cancer patients. Methods: the medical records of all consecutivewomen with high-risk endometrial cancer were reviewed. Results: among 92 high-risk endometrial cancer patients, 30 women experienced recurrence, and 21 women died. The 5-year PFS and OS probabilities were 65.3% and 75.9%, respectively. Multivariable Cox regression revealed that body mass index (hazard ratio (HR) = 1.11), paraaortic lymph node metastasis (HR = 11.11), lymphovascular space invasion (HR = 5.61), and sandwich chemoradiotherapy (HR = 0.15) were independently predictors of PFS. Body mass index (HR = 1.31), paraaortic lymph node metastasis (HR = 32.74), non-endometrioid cell type (HR = 11.31), and sandwich chemoradiotherapy (HR = 0.07) were independently predictors of OS. Among 51 women who underwent sandwich ( n = 35) or concurrent ( n = 16) chemoradiotherapy, the use of sandwich chemoradiotherapy were associated with better PFS (adjusted HR = 0.26, 95% CI = 0.08–0.87, p = 0.03) and OS (adjusted HR = 0.11, 95% CI = 0.02–0.71, p = 0.02) compared with concurrent chemoradiotherapy. Conclusion: compared with concurrent chemoradiotherapy, sandwich chemoradiotherapy was associated with better PFS and OS in high-risk endometrial cancer patients. In addition, high body mass index, paraaortic lymph node metastasis, and non-endometrioid cell type were also predictors of poor OS in high-risk endometrial cancer patients.

Keywords: endometrial neoplasms; recurrence; body mass index; chemotherapy; radiotherapy (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/17/16/5941/pdf (application/pdf)
https://www.mdpi.com/1660-4601/17/16/5941/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:17:y:2020:i:16:p:5941-:d:399636

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().