Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020

Giuseppina Campisi, Rodolfo Mauceri, Francesco Bertoldo, Giordana Bettini, Matteo Biasotto, Giuseppe Colella, Ugo Consolo, Olga Di Fede, Gianfranco Favia, Vittorio Fusco, Mario Gabriele, Antonio Lo Casto, Lorenzo Lo Muzio, Antonia Marcianò, Marco Mascitti, Marco Meleti, Michele D. Mignogna, Giacomo Oteri, Vera Panzarella, Umberto Romeo, Andrea Santarelli, Paolo Vescovi, Claudio Marchetti and Alberto Bedogni
Additional contact information
Giuseppina Campisi: Department of Surgical, Oncological, and Oral Sciences, University of Palermo, 90127 Palermo, Italy
Rodolfo Mauceri: Department of Surgical, Oncological, and Oral Sciences, University of Palermo, 90127 Palermo, Italy
Francesco Bertoldo: IAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy
Giordana Bettini: IAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy
Matteo Biasotto: Department of Medical, Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy
Giuseppe Colella: Department of Medical, Surgical and Dental Speciality, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Ugo Consolo: Department of Surgery, Medicine, Dentistry and Morphological Sciences with Transplant Surgery, Oncology and Regenerative Medicine Relevance, University of Modena and Reggio Emilia, 41125 Modena, Italy
Olga Di Fede: Department of Surgical, Oncological, and Oral Sciences, University of Palermo, 90127 Palermo, Italy
Gianfranco Favia: Department of Interdisciplinary Medicine, University of Bari Aldo Moro, 70124 Bari, Italy
Vittorio Fusco: IAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy
Mario Gabriele: Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56126 Pisa, Italy
Antonio Lo Casto: Department of Surgical, Oncological, and Oral Sciences, University of Palermo, 90127 Palermo, Italy
Lorenzo Lo Muzio: Department of Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, Italy
Antonia Marcianò: Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, Italy
Marco Mascitti: Department of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, 60126 Ancona, Italy
Marco Meleti: Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy
Michele D. Mignogna: Department of Neuroscience, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Napoli, Italy
Giacomo Oteri: Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, Italy
Vera Panzarella: Department of Surgical, Oncological, and Oral Sciences, University of Palermo, 90127 Palermo, Italy
Umberto Romeo: Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Roma, Italy
Andrea Santarelli: Department of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, 60126 Ancona, Italy
Paolo Vescovi: IAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy
Claudio Marchetti: IAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy
Alberto Bedogni: IAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy

IJERPH, 2020, vol. 17, issue 16, 1-15

Abstract: The Medication-Related Osteonecrosis of Jaws (MRONJ) diagnosis process and its prevention play a role of great and rising importance, not only on the Quality of Life (QoL) of patients, but also on the decision-making process by the majority of dentists and oral surgeons involved in MRONJ prevention (primary and secondary). The present paper reports the update of the conclusions from the Consensus Conference—held at the Symposium of the Italian Society of Oral Pathology and Medicine (SIPMO) (20 October 2018, Ancona, Italy)—after the newest recommendations (2020) on MRONJ were published by two scientific societies (Italian Societies of Maxillofacial Surgery and Oral Pathology and Medicine, SICMF and SIPMO), written on the inputs of the experts of the Italian Allied Committee on ONJ (IAC-ONJ). The conference focused on the topic of MRONJ, and in particular on the common practices at risk of inappropriateness in MRONJ diagnosis and therapy, as well as on MRONJ prevention and the dental management of patients at risk of MRONJ. It is a matter of cancer and osteometabolic patients that are at risk since being exposed to several drugs with antiresorptive (i.e., bisphosphonates and denosumab) or, more recently, antiangiogenic activities. At the same time, the Conference traced for dentists and oral surgeons some easy applicable indications and procedures to reduce MRONJ onset risk and to diagnose it early. Continuous updating on these issues, so important for the patient community, is recommended.

Keywords: MRONJ; prevention models; dentistry; oral surgery; bisphosphonates; denosumab; antiresorptive drugs; antiangiogenic agents; cancer; osteoporosis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations: View citations in EconPapers (9)

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