The Characteristic of Virulence, Biofilm and Antibiotic Resistance of Klebsiella pneumoniae

Guoying Wang, Guo Zhao, Xiaoyu Chao, Longxiang Xie and Hongju Wang
Additional contact information
Guoying Wang: Institute of Biomedical Informatics, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China
Guo Zhao: Institute of Biomedical Informatics, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China
Xiaoyu Chao: Institute of Biomedical Informatics, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China
Longxiang Xie: Institute of Biomedical Informatics, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China
Hongju Wang: Institute of Biomedical Informatics, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China

IJERPH, 2020, vol. 17, issue 17, 1-17

Abstract: Klebsiella pneumoniae is an important gram-negative opportunistic pathogen that causes a variety of infectious diseases, including urinary tract infections, bacteremia, pneumonia, and liver abscesses. With the emergence of multidrug-resistant (MDR) and hypervirulent K. pneumoniae ( hvKP ) strains, the rapid spread of these clinical strains in geography is particularly worrying. However, the detailed mechanisms of virulence and antibiotic resistance in K. pneumoniae are still not very clear. Therefore, studying and elucidating the pathogenic mechanisms and drug resistance mechanism of K. pneumoniae infection are important parts of current medical research. In this paper, we systematically summarized the virulence, biofilm, and antibiotic tolerance mechanisms of K. pneumoniae , and explored the application of whole genome sequencing and global proteomics, which will provide new clues for clinical treatment of K. pneumoniae .

Keywords: K. pneumoniae; pathogenicity; biofilm; multidrug-resistant (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.mdpi.com/1660-4601/17/17/6278/pdf (application/pdf)
https://www.mdpi.com/1660-4601/17/17/6278/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:17:y:2020:i:17:p:6278-:d:405648

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().