Night Shift Work, Chronotype, Sleep Duration, and Prostate Cancer Risk: CAPLIFE Study

Macarena Lozano-Lorca, Rocío Olmedo-Requena, María-Victoria Vega-Galindo, Fernando Vázquez-Alonso, Antonio Jiménez-Pacheco, Inmaculada Salcedo-Bellido, María-José Sánchez and José-Juan Jiménez-Moleón
Additional contact information
Macarena Lozano-Lorca: Universidad de Granada, Departamento de Medicina Preventiva y Salud Pública, 18016 Granada, Spain
Rocío Olmedo-Requena: Universidad de Granada, Departamento de Medicina Preventiva y Salud Pública, 18016 Granada, Spain
María-Victoria Vega-Galindo: Góngora Primary Health Care Centre, Distrito Sanitario Granada-Metropolitano, 18006 Granada, Spain
Fernando Vázquez-Alonso: Urology Department, Virgen de las Nieves University Hospital, 18014 Granada, Spain
Antonio Jiménez-Pacheco: Urology Department, San Cecilio University Hospital, 18016 Granada, Spain
Inmaculada Salcedo-Bellido: Universidad de Granada, Departamento de Medicina Preventiva y Salud Pública, 18016 Granada, Spain
María-José Sánchez: Universidad de Granada, Departamento de Medicina Preventiva y Salud Pública, 18016 Granada, Spain
José-Juan Jiménez-Moleón: Universidad de Granada, Departamento de Medicina Preventiva y Salud Pública, 18016 Granada, Spain

IJERPH, 2020, vol. 17, issue 17, 1-17

Abstract: To analyze the association between prostate cancer (PCa) risk and night shift work, chronotype, and sleep duration in the context of a population-based case-control study of incident prostate cancer in Spain, a total of 465 PCa cases and 410 controls were analyzed. Selection criteria were: (i) age 40–80 years, and (ii) residence in the coverage area of the reference hospitals for ≥6 months before recruitment. Exposure variables were: (i) night shift work (permanent or rotating); (ii) chronotype: morning, neither, or evening (Munich ChronoType Questionnaire) and (iii) sleep duration according to the recommendations of the American National Sleep Foundation. PCa aggressiveness was determined according to the International Society of Urology Pathology classification. Adjusted odds ratios (aOR) and 95% confidence intervals (95% CI) were estimated using logistic regression models. Night shift work was associated with PCa, aOR = 1.47 (95% CI 1.02–2.11), especially for rotating night shifts, aOR = 1.73 (95% CI 1.09–2.75). The magnitude of the association between ever night work and PCa was higher in evening subjects with aOR = 3.14 (95% CI 0.91–10.76) than in morning chronotypes with an aOR = 1.25 (95% CI 0.78–2.00). Working night shifts, especially rotating night shifts, could increase PCa risk. This risk may be higher in people with an evening chronotype.

Keywords: prostatic neoplasms; sleep; shift work schedule; circadian rhythm; case-control studies; CAPLIFE study (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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