Keratinocyte Growth Factor-1 Protects Radioiodine-Induced Salivary Gland Dysfunction in Mice

Jeong Mi Kim, Mi Eun Choi, Seok-Ki Kim, Ji Won Kim, Young-Mo Kim and Jeong-Seok Choi
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Jeong Mi Kim: Translational Research Center, Inha University, Incheon 22332, Korea
Mi Eun Choi: Translational Research Center, Inha University, Incheon 22332, Korea
Seok-Ki Kim: Department of Nuclear Medicine, National Cancer Center, Goyang 10408, Korea
Ji Won Kim: Translational Research Center, Inha University, Incheon 22332, Korea
Young-Mo Kim: Translational Research Center, Inha University, Incheon 22332, Korea
Jeong-Seok Choi: Translational Research Center, Inha University, Incheon 22332, Korea

IJERPH, 2020, vol. 17, issue 17, 1-9

Abstract: Background: Most patients with thyroid cancer suffer from salivary gland (SG) dysfunctions after radioiodine (RI) therapy. We investigated the effects of keratinocyte growth factor (KGF)-1 on RI-induced SG dysfunction in an animal model. Methods: Six C57BL/6 mice were assigned to each of the following groups: treatment naïve control group, RI group, and RI+KGF-1 group. Body and SG weights, salivary flow rates, salivary lag times and changes in 99mTc pertechnetate uptake and excretion were measured, and histologic changes were noted. Amylase activities and epidermal growth factor (EGF) concentrations in saliva were also measured. In addition, TUNEL assays were performed and apoptosis-related protein expressions were assessed. Results: RI-induced reductions in salivary flow rates and increases in salivary lag times observed in the RI group were not observed in RI+KGF-1 group. Mice in RI group had higher HIF1a levels than controls, but HIF1a levels in RI+KGF-1 group were similar to those in control group. Furthermore, mice in RI+KGF-1 group had more mucin stained acini and decreased periductal fibrosis than mice in RI group, and tissue remodeling of many salivary epithelial cells (AQP5) and endothelial cells (CD31) were observed in RI+KGF-1 group. Amylase activity and expression in saliva were greater in RI+KGF-1 group than in RI group, and fewer apoptotic cells were observed in RI+KGF-1 group. Furthermore, BCLxl (anti-apoptotic) expression was higher, and Bax (pro-apoptotic) expression was lower in RI+KGF-1 group than in RI group. Conclusions: Local delivery of KGF-1 might prevent RI-induced SG damage by reducing apoptosis.

Keywords: radioiodine; salivary gland; keratinocyte growth factor; anti-apoptosis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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