Separation and HPLC Characterization of Active Natural Steroids in a Standardized Extract from the Serratula coronata Herb with Antiseborrheic Dermatitis Activity

Marta Napierała, Joanna Nawrot, Justyna Gornowicz-Porowska, Ewa Florek, Arletta Moroch, Zygmunt Adamski, Anna Kroma, Izabela Miechowicz and Gerard Nowak
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Marta Napierała: Laboratory of Environmental Research, Department of Toxicology, Poznan University of Medical Sciences, 30 Dojazd Street, 60-631 Poznan, Poland
Joanna Nawrot: Department of Medicinal and Cosmetic Natural Products, Poznan University of Medical Sciences, 33 Mazowiecka Street, 60-623 Poznan, Poland
Justyna Gornowicz-Porowska: Department of Medicinal and Cosmetic Natural Products, Poznan University of Medical Sciences, 33 Mazowiecka Street, 60-623 Poznan, Poland
Ewa Florek: Laboratory of Environmental Research, Department of Toxicology, Poznan University of Medical Sciences, 30 Dojazd Street, 60-631 Poznan, Poland
Arletta Moroch: Department of Medicinal and Cosmetic Natural Products, Poznan University of Medical Sciences, 33 Mazowiecka Street, 60-623 Poznan, Poland
Zygmunt Adamski: Department of Dermatology, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-356 Poznan, Poland
Anna Kroma: Department of Medicinal and Cosmetic Natural Products, Poznan University of Medical Sciences, 33 Mazowiecka Street, 60-623 Poznan, Poland
Izabela Miechowicz: Department of Computer Science and Statistics, Poznan University of Medical Sciences, 79 Dabrowskiego Street, 60-529 Poznan, Poland
Gerard Nowak: Department of Medicinal and Cosmetic Natural Products, Poznan University of Medical Sciences, 33 Mazowiecka Street, 60-623 Poznan, Poland

IJERPH, 2020, vol. 17, issue 18, 1-12

Abstract: Phytoecdysteroids are natural compounds with therapeutic benefits in both humans and animals. The effectiveness of natural products with health potential is based on the activities and potencies of their active ingredients. In this study, dominant ecdysteroids—ajugasterone C, 20-hydroxyecdysone and polypodine B—from the Serratula coronata ( S. coronata ) herb were separated by column chromatography, identified by spectroscopic data and quantified by high-performance liquid chromatography with a diode array detector (HPLC-DAD). The obtained concentration of ecdysteroids (approximately 23%) in the S. coronatae herb extract enhances the possibility of their use in pharmaceutical and cosmetic products with high levels of phytoecdysteroids. Moreover, this study has shown a positive effect of ecdysteroids-containing cream on changes in quality of life and a beneficial effect in reducing the symptoms of seborrheic dermatitis. It has been demonstrated that the application of the cream with phytoecdysteroids resulted in a statistically significant alleviation of symptoms ( p < 0.05), especially in terms of itching, pain or burning sensations in the affected areas in comparison to previous symptoms.

Keywords: phytoecdysteroids; Serratula coronata; seborrheic dermatitis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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