Simple, Low-Cost and Long-Lasting Film for Virus Inactivation Using Avian Coronavirus Model as Challenge

Luiz Alberto Colnago, Iara Maria Trevisol, Daiane Voss Rech, Lucimara Aparecida Forato, Cirlei Igreja do Nascimento Mitre, José Paulo Gagliardi Leite, Rodrigo Giglioti and Cintia Hiromi Okino
Additional contact information
Luiz Alberto Colnago: Embrapa Instrumentação, Rua XV de Novembro 1452, São Carlos 13560-970, Brazil
Iara Maria Trevisol: Embrapa Suínos e Aves, Rodovia BR-153 Km 110, Concórdia 89715-899, Brazil
Daiane Voss Rech: Embrapa Suínos e Aves, Rodovia BR-153 Km 110, Concórdia 89715-899, Brazil
Lucimara Aparecida Forato: Embrapa Instrumentação, Rua XV de Novembro 1452, São Carlos 13560-970, Brazil
Cirlei Igreja do Nascimento Mitre: Instituto de Química de São Carlos Universidade de São Paulo, Av. Trabalhador São-Carlense 400, São Carlos 13566-590, Brazil
José Paulo Gagliardi Leite: Laboratório de Virologia Comparada e Ambiental, Instituto Oswaldo Cruz, Fiocruz, Avenida Brasil, 4365, Rio de Janeiro 21040-360, Brazil
Rodrigo Giglioti: Instituto de Zootecnia-IZ, Centro de Pesquisa de Genética e Reprodução Animal, Rua Heitor Penteado n.56, Nova Odessa 13380-011, Brazil
Cintia Hiromi Okino: Embrapa Pecuária Sudeste, Rodovia Washington Luiz Km 234 s/n, São Carlos 13560-970, Brazil

IJERPH, 2020, vol. 17, issue 18, 1-9

Abstract: The COVID-19 infection, caused by SARS-CoV-2, is inequitably distributed and more lethal among populations with lower socioeconomic status. Direct contact with contaminated surfaces has been among the virus sources, as it remains infective up to days. Several disinfectants have been shown to inactivate SARS-CoV-2, but they rapidly evaporate, are flammable or toxic and may be scarce or inexistent for vulnerable populations. Therefore, we are proposing simple, easy to prepare, low-cost and efficient antiviral films, made with a widely available dishwashing detergent, which can be spread on hands and inanimate surfaces and is expected to maintain virucidal activity for longer periods than the current sanitizers. Avian coronavirus (ACoV) was used as model of the challenge to test the antivirus efficacy of the proposed films. Polystyrene petri dishes were covered with a thin layer of detergent formula. After drying, the films were exposed to different virus doses for 10 min and virus infectivity was determined using embryonated chicken eggs, and RNA virus quantification in allantoic fluids by RT-qPCR. The films inactivated the ACoV (ranging from 10 3.7 to 10 6.7 EID 50 ), which is chemically and morphologically similar to SARS-CoV-2, and may constitute an excellent alternative to minimize the spread of COVID-19.

Keywords: coronavirus; film; detergent; antiviral; virucide; inactivation; sanitization (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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