A Scoping Review on Cue Reactivity in Methamphetamine Use Disorder

Lee Seng Esmond Seow, Wei Jie Ong, Aditi Hombali, P. V. AshaRani and Mythily Subramaniam
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Lee Seng Esmond Seow: Research Division, Institute of Mental Health, Buangkok Green Medical Park, Singapore 539747, Singapore
Wei Jie Ong: Research Division, Institute of Mental Health, Buangkok Green Medical Park, Singapore 539747, Singapore
Aditi Hombali: Research Division, Institute of Mental Health, Buangkok Green Medical Park, Singapore 539747, Singapore
P. V. AshaRani: Research Division, Institute of Mental Health, Buangkok Green Medical Park, Singapore 539747, Singapore
Mythily Subramaniam: Research Division, Institute of Mental Health, Buangkok Green Medical Park, Singapore 539747, Singapore

IJERPH, 2020, vol. 17, issue 18, 1-29

Abstract: The experience of craving via exposure to drug-related cues often leads to relapse in drug users. This study consolidated existing empirical evidences of cue reactivity to methamphetamine to provide an overview of current literature and to inform the directions for future research. The best practice methodological framework for conducting scoping review by Arkey and O’Malley was adopted. Studies that have used a cue paradigm or reported on cue reactivity in persons with a history of methamphetamine use were included. Databases such as Medline, EMBASE, PsycINFO and CINAHL were searched using key terms, in addition to citation check and hand search. The search resulted in a total of 32 original research articles published between 2006 to 2020. Three main themes with regard to cue reactivity were identified and synthesized: (1) effects of cue exposure, (2) individual factors associated with cue reactivity, and (3) strategies that modulate craving or reactivity to cues. Exposure to methamphetamine-associated cues elicits significant craving and other autonomic reactivity. Evidence suggests that drug cue reactivity is strongly associated with indices of drug use and other individual-specific factors. Future studies should focus on high quality studies to support evidence-based interventions for reducing cue reactivity and to examine cue reactivity as an outcome measure.

Keywords: methamphetamine use disorder; cue reactivity; cue-induced craving; cue exposure (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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