Suboptimal Serum 25-Hydroxy-Vitamin D Is Associated with a History of Recent Disease Exacerbation in Pediatric Patients with Bronchial Asthma or Asthma-Suggestive Recurrent Wheezing

Teodora-Irina Adam-Bonci, Paraschiva Cherecheș-Panța, Eduard-Alexandru Bonci, Sorin Claudiu Man, Ancuța Cutaș-Benedec, Tudor Drugan, Raluca Maria Pop and Alexandru Irimie
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Teodora-Irina Adam-Bonci: Pathophysiology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
Paraschiva Cherecheș-Panța: 3rd Pediatrics Clinic, Children’s Emergency Hospital Cluj-Napoca, 400217 Cluj-Napoca, Romania
Eduard-Alexandru Bonci: Oncological Surgery and Gynecologic Oncology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania
Sorin Claudiu Man: 3rd Pediatrics Clinic, Children’s Emergency Hospital Cluj-Napoca, 400217 Cluj-Napoca, Romania
Ancuța Cutaș-Benedec: Medical Informatics and Biostatistics, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania
Tudor Drugan: Medical Informatics and Biostatistics, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania
Raluca Maria Pop: Pharmacology, Toxicology and Clinical Pharmacology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania
Alexandru Irimie: Oncological Surgery and Gynecologic Oncology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania

IJERPH, 2020, vol. 17, issue 18, 1-11

Abstract: Even though vitamin D is widely acknowledged as having a potential immunomodulatory role in asthma, its exact beneficial mechanisms are yet to be clarified. An optimal serum 25-hydroxy-vitamin D (25-OH-VitD) level in pediatric asthma patients might not rely solely on the effect of dose-dependent vitamin D 3 intake, but might also be influenced by factors related to insufficient asthma control. We aimed to survey the prevalence of serum 25-OH-VitD deficiency and analyze whether suboptimal levels were associated with asthma severity factors. The current cross-sectional study enrolled 131 pediatric asthma or asthma-suggestive recurrent wheezing patients, for whom serum 25-OH-VitD, IgE, and eosinophil count were assessed. The prevalence of suboptimal serum 25-OH-VitD was 58.8%. A suboptimal vitamin D status was associated with asthma exacerbation in the previous month ( p = 0.02). Even under seasonal oral vitamin D 3 supplementation, patients with a positive history of asthma attack in the previous four weeks presented significantly lower serum 25-OH-VitD concentrations, compared to their peers with no disease exacerbation. In conclusion, sequential measurements of serum 25-OH-VitD might prove useful for future studies evaluating the dynamic changes in vitamin D 3 status in regard to asthma, especially in symptomatic patients.

Keywords: vitamin D; control of asthma; asthma exacerbation prevention; child (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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