Kinetics of IgG Antibodies in Previous Cases of Dengue Fever—A Longitudinal Serological Survey

Qilin Wu, Qinlong Jing, Xiujuan Wang, Lili Yang, Yilan Li, Zongqiu Chen, Mengmeng Ma and Zhicong Yang
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Qilin Wu: School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China
Qinlong Jing: Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Xiujuan Wang: School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
Lili Yang: Liwan District Center for Disease Control and Prevention, Guangzhou 510176, China
Yilan Li: Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Zongqiu Chen: Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Mengmeng Ma: Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Zhicong Yang: School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China

IJERPH, 2020, vol. 17, issue 18, 1-9

Abstract: Guangzhou is believed to be the most important epicenter of dengue outbreaks in southern China. In this study, a longitudinal serological investigation of previous cases of dengue fever in Guangzhou was conducted to explore the persistence of IgG antibodies and related factors affecting the changes of antibody level. We recruited 70 dengue virus type 1 (DENV-1) primary infection cases at two years post infection for serological investigation and conducted a second follow-up in the 5th year of prognosis. An enzyme-linked immunosorbent assay (ELISA) for DENV IgG antibody was examined in all study subjects. Potential factors associated with the concentration of serum total IgG antibody were determined by the generalized estimation equation (GEE). No significant difference in serum total IgG antibody positive rate between two follow-ups was observed ( χ 2 = 3.066, p = 0.080). However, there was a significant difference in the concentration of serum total IgG antibody between the two follow-ups (Z = 7.154, p < 0.001). The GEE showed that the antibody level in the five-year prognosis was mainly affected by the antibody level in the two-year prognosis (OR: 1.007, 95%CI: 1.005–1.009). In conclusion, the serum IgG antibodies of previous dengue fever cases can persist for a long time.

Keywords: dengue fever; antibody; kinetics; longitudinal investigation (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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