Evaluation of Salivary Matrix Metalloproteinase (MMP-8) in Periodontal Patients Undergoing Non-Surgical Periodontal Therapy and Mouthwash Based on Ozonated Olive Oil: A Randomized Clinical Trial

Gianna Maria Nardi, Francesca Cesarano, Giulio Papa, Lorella Chiavistelli, Roman Ardan, Maciej Jedlinski, Marta Mazur, Roberta Grassi and Felice Roberto Grassi
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Gianna Maria Nardi: Department of Dental and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy
Francesca Cesarano: Department of Dental and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy
Giulio Papa: Department of Dental and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy
Lorella Chiavistelli: Department of Dental and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy
Roman Ardan: Chair of Econometrics, Department of Economic Sciences, Koszalin University of Technology, 75-343 Koszalin, Poland
Maciej Jedlinski: Department of Interdisciplinary Dentistry, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland
Marta Mazur: Department of Dental and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy
Roberta Grassi: Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
Felice Roberto Grassi: Department of Basic Medical Sciences, Neurosciences and Sense Organs, Aldo Moro University of Bari, 70122 Bari, Italy

IJERPH, 2020, vol. 17, issue 18, 1-10

Abstract: Background : Extracellular matrix metalloproteinases (MMPs) play a pivotal role in the damage to the periodontal tissue in patients with periodontitis. Scaling and root planning (SRP) attempt to control the plaque amount and consequentially reduce the bacterial load. Non-surgical periodontal treatment could be integrated with drug therapy and physiotherapy procedures such as ozone therapy. The aim of this study was to evaluate in a cohort of patients with a diagnosis of periodontitis: (1) the efficacy of non-surgical periodontal therapy assisted by the use of ozonated olive oil-based mouthwash on salivary metalloproteinase (MMP-8) and (2) the reduction of periodontal indices. Methods : Ninety-six subjects with a diagnosis of periodontitis were enrolled in this study and randomly assigned to the study group (SRP + mouthwash) or control group (SRP). The study duration was 3 months. Data on MMP-8, plaque index (PI), bleeding on probing (BoP) and probing pocket depth (PPD) were recorded at T0, T1 (14 days), T2 (1 month) and T3 (6 months). Group differences were assessed using Student’s t -test for independent samples. Results: A significant improvement in PI, BoP, PPD and salivary MMP-8 levels was observed in both groups. An analysis of differences in relative changes of indices revealed the efficacy of ozonated olive oil in decreasing MMP-8 level. Simultaneously, it slowed the decrease of BoP index. Conclusions: Scaling and root plaining with the aid of ozonated olive oil mouthwash were found to be more effective on salivary MMP-8 reduction than scaling and root plaining alone.

Keywords: ozonated oil; periodontitis; salivary metalloproteinase; RCT; olive oil; ozone (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations: View citations in EconPapers (4)

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