Combined Toxicity of Cannabidiol Oil with Three Bio-Pesticides against Adults of Sitophilus Zeamais, Rhyzopertha Dominica, Prostephanus Truncatus and Trogoderma Granarium

Spiridon Mantzoukas, Nikolaos Kalyvas, Aristeidis Ntoukas, Ioannis Lagogiannis, Konstantinos Farsalinos, Panagiotis A. Eliopoulos and Konstantinos Poulas
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Spiridon Mantzoukas: Department of Pharmacy, University of Patras, 26504 Patras, Greece
Nikolaos Kalyvas: Department of Pharmacy, University of Patras, 26504 Patras, Greece
Aristeidis Ntoukas: Department of Pharmacy, University of Patras, 26504 Patras, Greece
Ioannis Lagogiannis: Department of Pharmacy, University of Patras, 26504 Patras, Greece
Konstantinos Farsalinos: Department of Pharmacy, University of Patras, 26504 Patras, Greece
Panagiotis A. Eliopoulos: Department of Agrotechnology, University of Thessaly, Gaiopolis, 41500 Larissa, Greece
Konstantinos Poulas: Department of Pharmacy, University of Patras, 26504 Patras, Greece

IJERPH, 2020, vol. 17, issue 18, 1-12

Abstract: The present study investigates the interaction between cannabidiol (CBD) oil and three biopesticides: Azatin and two baculovirus formulations (Madex and Helicovex), both separately and in combination, in order to investigate their interaction against adults of four major coleopteran stored-product pests: Sitophilus zeamais (Coleoptera: Curculionidae), Rhyzopertha dominica (Coleoptera: Bostrichidae), Prostephanus truncatus (Coleoptera: Bostrichidae) and Trogoderma granarium (Coleoptera: Dermestidae). CBD, which has been understudied for its insecticidal properties, was applied at three different doses (500, 1500 and 3000 ppm). The biopesticides were administered at 1500 ppm. Interactions in the combined treatments were mathematically estimated as not synergistic and mostly competitive except for the combined treatments of CBD (1500 and 3000 ppm) with Azatin (1500 ppm) which were marked by an additive interaction. In its individual application, CBD oil generated the highest insect mortality while its effect was clearly dose-dependent. The findings reveal a promising effect of CBD oil against these coleopterans which had not been previously tested together.

Keywords: CBD oil; biopesticides; stored pests; insecticidal; Azatin; madex; helicovex (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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