Tuberculosis Infection Screening in 5468 Italian Healthcare Students: Investigation of a Borderline Zone Value for the QFT-Test

Anna Rita Corvino, Maria Grazia Lourdes Monaco, Elpidio Maria Garzillo, Elena Grimaldi, Giovanna Donnarumma, Nadia Miraglia, Gabriella Di Giuseppe and Monica Lamberti
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Anna Rita Corvino: Experimental Medicine Department, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Maria Grazia Lourdes Monaco: Occupational Medicine Unit, University Hospital of Verona, 37134 Verona, Italy
Elpidio Maria Garzillo: Experimental Medicine Department, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Elena Grimaldi: Experimental Medicine Department, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Giovanna Donnarumma: Experimental Medicine Department, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Nadia Miraglia: Experimental Medicine Department, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Gabriella Di Giuseppe: Experimental Medicine Department, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Monica Lamberti: Experimental Medicine Department, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy

IJERPH, 2020, vol. 17, issue 18, 1-9

Abstract: Healthcare workers are at an increased risk of contracting Mycobacterium tuberculosis infection. Tuberculin skin test (TST) and interferon gamma release assay (IGRA) represent the available tests most used for the diagnosis of latent tuberculosis infection (LTBI). Different borderline zones have been proposed for defining conversions and reversions to improve the interpretation of the IGRA test results as part of serial testing. From 2012 to 2017, 5468 health students of an Italian University Hospital were screened for tuberculosis infection through the execution of the TST and, in case of positivity, of the QuantiFERON-TB ® Gold In-Tube assay (QFT–GIT). The QFT–GIT is considered “borderline” with values from 0.35 to 0.99 IU/mL. Among the students who performed the QFT–GIT assay, 27 subjects presented a range of values defined as borderline. The QFT–GIT was repeated after 90 days on 19 subjects with borderline values and showed a negativization of the values in 14 students and a positive conversion in three cases, while for two students, a borderline value was also found for the second test, with a 74% regression of the borderline cases. The introduction of QuantiFERON borderline values is a useful assessment tool to bring out LTBI case candidates for chemoprophylaxis.

Keywords: Mycobacterium tuberculosis infection; healthcare workers; QuantiFERON serial testing; LTBI (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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