Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis

Alicia Saz-Lara, Celia Álvarez-Bueno, Vicente Martínez-Vizcaíno, Blanca Notario-Pacheco, Irene Sequí-Dominguez and Iván Cavero-Redondo
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Alicia Saz-Lara: Health and Social Research Center, Universidad de Castilla-La Mancha, 16171 Cuenca, Spain
Celia Álvarez-Bueno: Health and Social Research Center, Universidad de Castilla-La Mancha, 16171 Cuenca, Spain
Vicente Martínez-Vizcaíno: Health and Social Research Center, Universidad de Castilla-La Mancha, 16171 Cuenca, Spain
Blanca Notario-Pacheco: Health and Social Research Center, Universidad de Castilla-La Mancha, 16171 Cuenca, Spain
Irene Sequí-Dominguez: Health and Social Research Center, Universidad de Castilla-La Mancha, 16171 Cuenca, Spain
Iván Cavero-Redondo: Health and Social Research Center, Universidad de Castilla-La Mancha, 16171 Cuenca, Spain

IJERPH, 2020, vol. 17, issue 18, 1-14

Abstract: Evidence exists regarding the association between advanced glycation end products and different cardiovascular disease subclinical processes, such as arterial stiffness and atherosclerosis. With this systematic review and meta-analysis, we aimed to provide a synthesis of the evidence regarding the association of arterial stiffness measured by pulse wave velocity and atherosclerosis measured by carotid intima media thickness with skin autofluorescence. A systematic search was performed using: MEDLINE (PubMed), SCOPUS, and Web of Science, until 30 March 2020. Cross-sectional studies or baseline data from prospective longitudinal studies were considered. The DerSimonian and Laird method was used to calculate the pooled estimates of correlation coefficients and the corresponding 95% confidence intervals (CI) for the association of pulse wave velocity and carotid intima media thickness with skin autofluorescence. Twenty-five studies were included in the systematic review and meta-analysis, including 6306 subjects. The pooled correlation coefficient was 0.25 (95% CI: 0.18, 0.31) for pulse wave velocity and skin autofluorescence, and 0.31 (95% CI: 0.25, 0.38) for carotid intima media thickness and skin autofluorescence. This systematic review and meta-analysis provide a synthesis of the evidence showing a positive weak association of pulse wave velocity and carotid intima media thickness with skin autofluorescence.

Keywords: cardiovascular disease; skin autofluorescence; advanced glycation end products; arterial stiffness; pulse wave velocity; carotid intima media thickness (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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