Metabolically Healthy Obesity: Presence of Arterial Stiffness in the Prepubescent Population

Maria Isabel Ruiz-Moreno, Alberto Vilches-Perez, Cristina Gallardo-Escribano, Antonio Vargas-Candela, Maria Dolores Lopez-Carmona, Luis Miguel Pérez-Belmonte, Alejandro Ruiz-Moreno, Ricardo Gomez-Huelgas and Maria Rosa Bernal-Lopez
Additional contact information
Maria Isabel Ruiz-Moreno: Internal Medicine Department, Instituto de Investigacion Biomedica de Malaga (IBIMA), Regional University Hospital of Malaga, 29010 Malaga, Spain
Alberto Vilches-Perez: Endocrinology and Nutrition Department, Instituto de Investigacion Biomedica de Malaga (IBIMA), University Hospital Virgen de la Victoria, 29010 Malaga, Spain
Cristina Gallardo-Escribano: Clinical Analysis Department, Regional University Hospital of Malaga, 29010 Malaga, Spain
Antonio Vargas-Candela: Internal Medicine Department, Instituto de Investigacion Biomedica de Malaga (IBIMA), Regional University Hospital of Malaga, 29010 Malaga, Spain
Maria Dolores Lopez-Carmona: Internal Medicine Department, Instituto de Investigacion Biomedica de Malaga (IBIMA), Regional University Hospital of Malaga, 29010 Malaga, Spain
Luis Miguel Pérez-Belmonte: Internal Medicine Department, Instituto de Investigacion Biomedica de Malaga (IBIMA), Regional University Hospital of Malaga, 29010 Malaga, Spain
Alejandro Ruiz-Moreno: Internal Medicine Department, Instituto de Investigacion Biomedica de Malaga (IBIMA), Regional University Hospital of Malaga, 29010 Malaga, Spain
Ricardo Gomez-Huelgas: Internal Medicine Department, Instituto de Investigacion Biomedica de Malaga (IBIMA), Regional University Hospital of Malaga, 29010 Malaga, Spain
Maria Rosa Bernal-Lopez: Internal Medicine Department, Instituto de Investigacion Biomedica de Malaga (IBIMA), Regional University Hospital of Malaga, 29010 Malaga, Spain

IJERPH, 2020, vol. 17, issue 19, 1-10

Abstract: Aim: Arteriosclerotic cardiovascular disease, one of the world’s leading causes of death, first manifests itself at an early age. The identification of children who may have increased cardiovascular risk in the future could be an important prevention strategy. Our aim was to assess the clinical, analytical, and dietary variables associated with arterial stiffness (AS), measured by carotid-femoral pulse wave velocity (cfPWV) in a prepubescent population with metabolically healthy obesity (MHO). Subjects and Methods: A cross-sectional study in prepubescent subjects with obesity who had ≤1 metabolic syndrome criteria (abdominal perimeter and blood pressure ≥90th percentile, triglycerides >150 mg/dL, HDL-cholesterol <40 mg/dL, fasting plasma glucose ≥100 mg/dL) was conducted. Adherence to Mediterranean Diet, blood pressure, BMI, waist/height ratio (WHtR), glycemic status, lipid profile, and cfPWV were analyzed. 75 MHO children (boys: 43; girls: 32; p = 0.20) (age = 10.05 ± 1.29 years; BMI = 25.29 ± 3.5 kg/m2) were included. Results: We found a positive correlation between cfPWV and weight (r = 0.51; p < 0.0001), BMI (r = 0.44; p < 0.0001), WHtR (r = 0.26; p = 0.02), fasting insulin levels (r = 0.28; p = 0.02), and insulin resistance (Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index) (r = 0.25; p = 0.04). Multiple linear regression analysis identified BMI and HOMA-IR as independent parameters associated with cfPWV. Conclusions: Prepubescent children with obesity who were shown to be metabolically healthy presented with arterial stiffness, which is closely related to BMI and the state of insulin resistance.

Keywords: arterial stiffness; carotid-femoral pulse wave velocity; prepubescent population; Mediterranean diet; insulin resistance; metabolically healthy obesity (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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Citations: View citations in EconPapers (2)

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