Comparison between Gradual Reduced Nicotine Content and Usual Nicotine Content Groups on Subjective Cigarette Ratings in a Randomized Double-Blind Trial

Wenxue Lin, Nicolle M. Krebs, Junjia Zhu, Jonathan Foulds, Kimberly Horn and Joshua E. Muscat
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Wenxue Lin: Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Nicolle M. Krebs: Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Junjia Zhu: Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Jonathan Foulds: Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Kimberly Horn: Department of Population Health Sciences, Virginia Tech Carilion Research Institute, Roanoke, VA 24016, USA
Joshua E. Muscat: Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA

IJERPH, 2020, vol. 17, issue 19, 1-9

Abstract: In 2018, the United States Food and Drug Administration (FDA) issued an advanced notice of proposed rulemaking to reduce nicotine in tobacco products to produce a minimally addictive or nonaddictive effect, but there was a research gap in the subjective responses of reduced-nicotine-content cigarettes. We compared the responses of the modified cigarette evaluation questionnaire (mCEQ) and cigarette-liking scale (CLS) between the gradually reduced nicotine content (RNC) group and the usual nicotine content (UNC) group. Linear mixed-effects models for repeated measures were used to analyze and compare the change over time for the mCEQ and CLS across the two treatment groups (RNC and UNC). We found that the change over time for the mCEQ and CLS was significant between the RNC and the UNC treatment groups at the beginning of visit 6 with 1.4 mg nicotine/cigarette. At visits 8 and 9, the RNC group reported significantly lower satisfaction scores compared to UNC. Subscale analysis showed that smoking satisfaction decreased in RNC while other measures, such as cigarette enjoyment, did not change. Understanding the impact of nicotine reduction on cigarette subjective responses through evaluation and liking scales would provide valuable information to the FDA on nicotine reduction policies for cigarettes.

Keywords: reduced nicotine content; usual nicotine content; modified cigarette evaluation questionnaire; cigarette-liking scale (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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