Change in Oxidative Stress Biomarkers During 30 Days in Saturation Dive: A Pilot Study

Simona Mrakic-Sposta, Alessandra Vezzoli, Federica D’Alessandro, Matteo Paganini, Cinzia Dellanoce, Danilo Cialoni and Gerardo Bosco
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Simona Mrakic-Sposta: Institute of Clinical Physiology, National Research Council (CNR), 20162 Milan, Italy
Alessandra Vezzoli: Institute of Clinical Physiology, National Research Council (CNR), 20162 Milan, Italy
Federica D’Alessandro: Department of Biomedical Sciences, Environmental and Respiratory Physiology, University of Padova, 35122 Padova, Italy
Matteo Paganini: Department of Biomedical Sciences, Environmental and Respiratory Physiology, University of Padova, 35122 Padova, Italy
Cinzia Dellanoce: Institute of Clinical Physiology, National Research Council (CNR), 20162 Milan, Italy
Danilo Cialoni: Department of Biomedical Sciences, Environmental and Respiratory Physiology, University of Padova, 35122 Padova, Italy
Gerardo Bosco: Department of Biomedical Sciences, Environmental and Respiratory Physiology, University of Padova, 35122 Padova, Italy

IJERPH, 2020, vol. 17, issue 19, 1-10

Abstract: Saturation diving allows divers to reduce the risk of decompression sickness while working at depth for prolonged periods but may increase reactive oxygen species (ROS) production. Such modifications can affect endothelial function by exacerbating oxidative stress. This study investigated the effects of saturation diving on oxidative stress damage. Redox status was evaluated through: ROS production; total antioxidant capacity (TAC); nitric oxide metabolites (NOx); nitrotyrosine (3-NT); and lipid peroxidation (8-iso-PGF2α) assessment. Creatinine and neopterin were analyzed as markers of renal function and damage. Measurements were performed on saliva and urine samples obtained at four time points: pre; deep; post; and 24 h post. Four divers were included in the study. After the saturation dive (post), significant ( p < 0.05) increases in ROS (0.12 ± 0.03 vs. 0.36 ± 0.06 µmol.min −1 ), TAC (1.88 ± 0.03 vs. 2.01 ± 0.08 mM), NOx (207.0 ± 103.3 vs. 441.8 ± 97.3 µM), 3-NT (43.32 ± 18.03 vs. 18.64 ± 7.45 nM·L −1 ), and 8-iso-PGF2α (249.7 ± 45.1 vs. 371.9 ± 54.9 pg·mg −1 creatinine) were detected. Markers of renal damage were increased as well after the end of the saturation dive (creatinine 0.54 ± 0.22 vs. 2.72 ± 1.12 g-L −1 ; neopterin 73.3 ± 27.9 vs. 174.3 ± 20.53 μmol·mol −1 creatinine). These results could ameliorate commercial or military diving protocols or improve the understanding of symptoms caused by oxygen level elevation.

Keywords: saturation diving; hyperbaria; reactive oxygen species; nitric oxide; electron paramagnetic resonance (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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