Gestational Pesticide Exposure and Child Respiratory Health

Robyn Gilden, Erika Friedmann, Katie Holmes, Kimberly Yolton, Yingying Xu, Bruce Lanphear, Aimin Chen, Joseph Braun and Adam Spanier
Additional contact information
Robyn Gilden: Department of Family and Community Health, University of Maryland School of Nursing, Baltimore, MD 21201, USA
Erika Friedmann: Office of Research and Scholarship, University of Maryland School of Nursing, Baltimore, MD 21201, USA
Katie Holmes: Office of Research and Scholarship, University of Maryland School of Nursing, Baltimore, MD 21201, USA
Kimberly Yolton: Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Yingying Xu: Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Bruce Lanphear: Department of Health Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada
Aimin Chen: Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
Joseph Braun: Department of Epidemiology, Brown University, Providence, RI 02912, USA
Adam Spanier: Department of Pediatrics, Division of General Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA

IJERPH, 2020, vol. 17, issue 19, 1-18

Abstract: Background: Childhood wheeze may be related to pesticide exposure, and diet and genetics (Paroxonase; PON1 ) may modify the effects of exposure. Methods: We analyzed data from the HOME Study, a prospective pregnancy and birth cohort, to examine the association of gestational urinary organophosphate (OP) and pyrethroid (3PBA) metabolite concentrations with child wheeze, forced expiratory volume in one second (FEV1) at ages 4 and 5 years, and wheeze trajectory patterns through age 8 years. Results: Among 367 singletons, the frequency of wheeze ranged from 10.6% to 24.1% at each measurement age. OP and 3PBA metabolite concentrations were not associated with wheeze at 8 years or from birth to 8 years, but there were three significant interactions: (1) maternal daily fruit and vegetable consumption (less than daily consumption and increasing 3PBA was associated with wheeze at age 8 years, OR = 1.40), (2) maternal PON1 - 108 allele (CT/TT genotypes and high DE was associated with wheeze at age 8 years, OR = 2.13, 2.74) and (3) PON1 192 alleles (QR/RR genotypes with higher diethylphosphate (DE) and dialkyl phosphate (DAP) were associated with wheeze at age 8 years, OR = 3.84). Pesticide metabolites were not consistently related to FEV1 or wheeze trajectory. Conclusions: Gestational OP and 3PBA metabolites were associated with child respiratory outcomes in participants with maternal dietary and genetic susceptibility.

Keywords: organophosphates; pyrethroids; gestational exposure; children; wheeze (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.mdpi.com/1660-4601/17/19/7165/pdf (application/pdf)
https://www.mdpi.com/1660-4601/17/19/7165/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:17:y:2020:i:19:p:7165-:d:421958

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().