Responders to Exercise Therapy in Patients with Osteoarthritis of the Hip: A Systematic Review and Meta-Analysis

Carolien H. Teirlinck, Arianne P. Verhagen, Elja A.E. Reijneveld, Jos Runhaar, Marienke van Middelkoop, Leontien M. van Ravesteyn, Lotte Hermsen, Ingrid B. de Groot and Sita M.A. Bierma-Zeinstra
Additional contact information
Carolien H. Teirlinck: Department of General Practice, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
Arianne P. Verhagen: Department of General Practice, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
Elja A.E. Reijneveld: Department of General Practice, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
Jos Runhaar: Department of General Practice, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
Marienke van Middelkoop: Department of General Practice, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
Leontien M. van Ravesteyn: Discipline of Physiotherapy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, Australia
Lotte Hermsen: National Health Care Institute, 1110 AH Diemen, The Netherlands
Ingrid B. de Groot: National Health Care Institute, 1110 AH Diemen, The Netherlands
Sita M.A. Bierma-Zeinstra: Department of General Practice, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands

IJERPH, 2020, vol. 17, issue 20, 1-13

Abstract: The Outcome Measures in Rheumatology workgroup (OMERACT), together with the Osteoarthritis Research Society International (OARSI) developed the OMERACT-OARSI responder criteria. These criteria are used to determine if a patient with osteoarthritis (OA) ‘responds’ to therapy, meaning experiences a clinically relevant effect of therapy. Recently, more clinical OA trials report on this outcome and most OA trials have data to calculate the number of responders according to these criteria. A systematic review and meta-analysis were performed on the response to exercise therapy, compared to no or minimal intervention in patients with hip OA using the OMERACT-OARSI responder criteria. The literature was searched for relevant randomized trials. If a trial fit the inclusion criteria, but number of responders was not reported, the first author was contacted. This way the numbers of responders of 14 trials were collected and a meta-analysis on short term (directly after treatment, 12 trials n = 1178) and long term (6–8 months after treatment, six trials n = 519) outcomes was performed. At short term, the risk difference (RD) was 0.14 (95% confidence interval (CI) 0.06–0.22) and number needed to treat (NNT) 7.1 (95% CI 4.5–17); at long term RD was 0.14 (95% CI 0.07–0.20) and NNT 7.1 (95% CI 5.0–14.3). Quality of evidence was moderate for the short term and high for the long term. In conclusion, 14% more hip OA patients responded to exercise therapy than to no therapy.

Keywords: hip osteoarthritis; exercise therapy; responders; meta-analysis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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