Environmental Epigenetics of Diesel Particulate Matter Toxicogenomics

Stephanie M. Bilinovich, Kristy Lewis, Barbara L. Thompson, Jeremy W. Prokop and Daniel B. Campbell
Additional contact information
Stephanie M. Bilinovich: Department of Pediatrics & Human Development, Michigan State University, Grand Rapids, MI 49503, USA
Kristy Lewis: Department of Pediatrics & Human Development, Michigan State University, Grand Rapids, MI 49503, USA
Barbara L. Thompson: Department of Pediatrics & Human Development, Michigan State University, Grand Rapids, MI 49503, USA
Jeremy W. Prokop: Department of Pediatrics & Human Development, Michigan State University, Grand Rapids, MI 49503, USA
Daniel B. Campbell: Department of Pediatrics & Human Development, Michigan State University, Grand Rapids, MI 49503, USA

IJERPH, 2020, vol. 17, issue 20, 1-13

Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by disruptions in social communication and behavioral flexibility. Both genetic and environmental factors contribute to ASD risk. Epidemiologic studies indicate that roadway vehicle exhaust and in utero exposure to diesel particulate matter (DPM) are associated with ASD. Using the Comparative Toxicogenomics Database (CTD), we identified genes connected to DPM exposure and ASD, extracted the known enhancers/promoters of the identified genes, and integrated this with Assay for Transposase Accessible Chromatin (ATAC-seq) data from DPM-exposed human neural progenitor cells. Enhancer/promoter elements with significantly different chromosome accessibility revealed enriched DNA sequence motifs with transcription factor binding sites for EGR1. Variant extraction for linkage disequilibrium blocks of these regions followed by analysis through Genome Wide Association Studies (GWAS) revealed multiple neurological trait associations including exploratory eye movement and brain volume measurement. This approach highlights the effects of pollution on the regulatory regions of genes implicated in ASD by genetic studies, indicating convergence of genetic and environmental factors on molecular networks that contribute to ASD. Integration of publicly available data from the CTD, cell culture exposure studies, and phenotypic genetics synergize extensive evidence of chemical exposures on gene regulation for altered brain development.

Keywords: autism spectrum disorder; diesel particulate matter; epigenetics; toxicogenomics (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/17/20/7386/pdf (application/pdf)
https://www.mdpi.com/1660-4601/17/20/7386/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:17:y:2020:i:20:p:7386-:d:425865

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().