Polymorphisms in GP6, PEAR1A, MRVI1, PIK3CG, JMJD1C, and SHH Genes in Patients with Unstable Angina

Rafał Rudzik, Violetta Dziedziejko, Monika Ewa Rać, Marek Sawczuk, Agnieszka Maciejewska-Skrendo, Krzysztof Safranow and Andrzej Pawlik
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Rafał Rudzik: Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland
Violetta Dziedziejko: Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111 Szczecin, Poland
Monika Ewa Rać: Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111 Szczecin, Poland
Marek Sawczuk: Insitute of Physical Culture Sciences, University of Szczecin, 70-111 Szczecin, Poland
Agnieszka Maciejewska-Skrendo: Faculty of Physical Culture, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
Krzysztof Safranow: Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111 Szczecin, Poland
Andrzej Pawlik: Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland

IJERPH, 2020, vol. 17, issue 20, 1-14

Abstract: Introduction: Coronary artery disease (CAD) is a significant public health problem because it is one of the major causes of death worldwide. Several studies have investigated the associations between CAD and polymorphisms in genes connected with platelet aggregation and the risk of venous thromboembolism. Aim: In this study, we examined the associations between polymorphisms in GP6 (rs1671152), PEAR1A (rs12566888), MRVI1 (rs7940646), PIK3CG (rs342286), JMJD1C (rs10761741), SHH (rs2363910), and CAD in the form of unstable angina as well as selected clinical and biochemical parameters. The study enrolled 246 patients with diagnosed unstable angina and 189 healthy controls. Results: There were no significant differences in the distribution of the studied polymorphisms between the patients with unstable angina and the controls. In patients with the GP6 rs1671152 GG genotype, we observed increased BMI values and an increased frequency of type 2 diabetes diagnosis. Conclusions: The results of this study suggest a lack of association between GP6 (rs1671152), PEAR1A (rs12566888), MRVI1 (rs7940646), PIK3CG (rs342286), JMJD1C (rs10761741), SHH (rs2363910), and unstable angina. The results indicate an association between GP6 (rs1671152) and type 2 diabetes.

Keywords: coronary artery disease; unstable angina; venous thromboembolism; platelet aggregation; polymorphism (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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