Hypertension Is Associated with Increased Risk of Diabetic Lung

Jihyun Lee, Donghwan Kwon, Youngjang Lee, Inchan Jung, Daesung Hyun, Hunju Lee and Yeon-Soon Ahn
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Jihyun Lee: Department of Medicine, Wonju College of Medicine, Yonsei University, 20 Ilsan-ro, Wonju 26426, Korea
Donghwan Kwon: Department of Medicine, Wonju College of Medicine, Yonsei University, 20 Ilsan-ro, Wonju 26426, Korea
Youngjang Lee: Department of Medicine, Wonju College of Medicine, Yonsei University, 20 Ilsan-ro, Wonju 26426, Korea
Inchan Jung: Department of Medicine, Wonju College of Medicine, Yonsei University, 20 Ilsan-ro, Wonju 26426, Korea
Daesung Hyun: Department of Preventive Medicine, Wonju College of Medicine, Yonsei University, 20 Ilsan-ro, Wonju 26426, Korea
Hunju Lee: Department of Preventive Medicine, Wonju College of Medicine, Yonsei University, 20 Ilsan-ro, Wonju 26426, Korea
Yeon-Soon Ahn: Department of Preventive Medicine and Genomic Cohort Institute, Yonsei Wonju College of Medicine, Yonsei University, Wonju 26426, Korea

IJERPH, 2020, vol. 17, issue 20, 1-11

Abstract: Lung function is often impaired in diabetic patients, especially in a restrictive pattern, which has recently been described as the diabetic lung. Since hypertension (HTN) is common in diabetic patients, our study investigated whether HTN acts as an aggravating factor in diabetic lung. Within the cross-sectional study from the 6th Korean National Health and Nutrition Examination Survey (KNHANES), fasting plasma glucose (FPG), blood pressure (BP), pulmonary function, and laboratory data were examined in 4644 subjects aged between 40 and 79 years. A multivariate regression model was used to investigate the relationship between BP, FPG, and pulmonary function. Lung function was significantly reduced in the HTN ( p = 0.001), impaired fasting glucose (IFG) ( p < 0.001), and diabetes mellitus (DM) ( p < 0.001) groups. Next, a multivariate logistic regression model was used to derive the odds ratio (OR) of reduced lung function based on the presence of IFG, DM, and HTN. The OR of reduced forced vital capacity (FVCp < 80%) was 3.30 ( p < 0.001) in the HTN-DM group and 2.30 ( p < 0.001) in the normal BP-DM group, when compared with the normal BP-normal FPG group. The combination of HTN and DM had the strongest negative effect on FVC. The results presented in this study indicate that diabetes and hypertension have a synergistic association with impaired lung function.

Keywords: diabetic lung; hypertension; diabetes; impaired fasting glucose; pulmonary function (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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