Relations of Psychosocial Factors and Cortisol with Periodontal and Bacterial Parameters: A Prospective Clinical Study in 30 Patients with Periodontitis Before and After Non-Surgical Treatment

Marie Dubar, Isabelle Clerc-Urmès, Cédric Baumann, Céline Clément, Corentine Alauzet and Catherine Bisson
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Marie Dubar: Department of Periodontology, School of Dentistry, Lille University Hospital, 59000 Lille, France
Isabelle Clerc-Urmès: Department of Methodology, Promotion and Investigation, UMDS, University Hospital of Nancy, 54500 Vandoeuvre-lès-Nancy, France
Cédric Baumann: Department of Methodology, Promotion and Investigation, UMDS, University Hospital of Nancy, 54500 Vandoeuvre-lès-Nancy, France
Céline Clément: CHRU Nancy, Department of Public Health Dentistry, University Hospital, 54000 Nancy, France
Corentine Alauzet: Stress Immunity Pathogens Unit (SIMPA), EA 7300, University of Lorraine, F-54000 Nancy, France
Catherine Bisson: Stress Immunity Pathogens Unit (SIMPA), EA 7300, University of Lorraine, F-54000 Nancy, France

IJERPH, 2020, vol. 17, issue 20, 1-19

Abstract: (1) Background: The progression of periodontitis, induced by polymicrobial dysbiosis, can be modified by systemic or environmental factors such as stress or anxiety affecting host response. The purpose of this study is to evaluate the potential associations between psychosocial factors scores or salivary cortisol levels with clinical periodontal parameters and bacterial environment in patients with periodontitis; (2) Methods: Subgingival microbiota was collected in two pathological and one healthy sites from thirty diseased patients (before/after scaling and root planing (SRP)) and from one healthy site from thirty control patients. Usual clinical periodontal parameters were recorded, and a saliva sample was harvested. Patients completed stress and anxiety self-assessment questionnaires. Cortisol concentrations were determined by ELISA and bacteria were identified by PCR; (3) Results: No correlation between salivary cortisol and the stress-anxiety self-declared was found ( p > 0.05), but high concentrations of this molecule were associated positively and linearly with periodontal pocket depth ( p = 0.04). It appeared that certain psychosocial stressors are associated with a modulation of the bacterial colonization of pockets of diseased group (before/after SRP), notably concerning Tannerella forsythia ( p = 0.02), Porphyromonas gingivalis ( p = 0.03), Fusobacterium nucleatum ( p = 0.049) and Campylobacter rectus ( p = 0.01). (4) Conclusion: This study reveals associations between bacteria colonization and psychosocial parameters in periodontitis that needs to be further investigated.

Keywords: periodontitis; stress; anxiety; cortisol; periodontal parameters; periodontal therapy; periodontal bacteria (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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