Roma Ethnicity and Sex-Specific Associations of Serum Uric Acid with Cardiometabolic and Hepatorenal Health Factors in Eastern Slovakian Population: The HepaMeta Study

Maria Pallayova, Marek Brenisin, Alina Putrya, Martin Vrsko, Sylvia Drazilova, Martin Janicko, Maria Marekova, Daniel Pella, Andrea Madarasova Geckova, Peter Urdzik, Peter Jarcuska and HepaMeta Team
Additional contact information
Maria Pallayova: Department of Medical Physiology, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
Marek Brenisin: Department of Pathological Physiology, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
Alina Putrya: 2nd Department of Cardiology, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
Martin Vrsko: Department of Internal Medicine, AGEL Hospital, Kosice-Saca, 04015 Kosice, Slovakia
Sylvia Drazilova: 2nd Department of Internal Medicine, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
Martin Janicko: 2nd Department of Internal Medicine, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
Maria Marekova: Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
Daniel Pella: 2nd Department of Cardiology, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
Andrea Madarasova Geckova: Department of Health Psychology, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
Peter Urdzik: Louis Pasteur University Hospital, 04011 Kosice, Slovakia
Peter Jarcuska: 2nd Department of Internal Medicine, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
HepaMeta Team: HepaMeta Team members are listed in Appendix A .

IJERPH, 2020, vol. 17, issue 20, 1-15

Abstract: Background: Health characteristics associated with uric acid (UA) in the Roma minority remain less well known. The study sought to determine the ethnicity- and sex-specific associations of serum UA with health factors in Eastern Slovakian Roma and non-Roma populations. Methods: Data from the comparative cross-sectional HepaMeta study conducted in Slovakia in 2011 were used. The study enrolled 452 Roma subjects (35.2% men) and 403 non-Roma individuals (45.9% men) aged 18–55 years. Results: All study parameters differed between the sexes in both the Roma and non-Roma participants ( p < 0.05). UA was related to sex with odds ratio for female sex 0.873, 95% CI 0.853–0.893 ( p < 0.0001) per 10-unit increase of UA. Average level of UA ± standard deviation was lower in Roma than in non-Roma (226.54 ± 79.8 vs. 259.11 ± 84.53 umol/L; p < 0.0001). The Roma population presented with greater levels of high-sensitivity C-reactive protein (hsCRP) (3.07 ± 4 mg/L vs. 1.98 ± 2.83 mg/L; p < 0.0001) and ferritin in Roma males (403.78 ± 391.84 vs. 302.67 ± 236.26 mg/L; p < 0.0001). Conclusions: Serum UA is sex- and ethnicity specific. Elevated levels of hsCRP and ferritin particularly in Roma males can reflect low-grade systemic inflammation and thus serve as a marker of an increased cardiovascular risk.

Keywords: C-reactive protein; health status; Roma; sex; uric acid (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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