Hyperbaric Oxygen Exposure Attenuates Circulating Stress Biomarkers: A Pilot Interventional Study

Jae Seung Chang, Eunha Chang, Yoonsuk Lee, Yong Sung Cha, Seung-Kuy Cha, Won Gil Cho, Yangsik Jeong, Hyun Kim and Kyu-Sang Park
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Jae Seung Chang: Mitohormesis Research Center, Yonsei University Wonju College of Medicine, Wonju, Gangwon-Do 26426, Korea
Eunha Chang: Mitohormesis Research Center, Yonsei University Wonju College of Medicine, Wonju, Gangwon-Do 26426, Korea
Yoonsuk Lee: Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Gangwon-Do 26426, Korea
Yong Sung Cha: Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Gangwon-Do 26426, Korea
Seung-Kuy Cha: Mitohormesis Research Center, Yonsei University Wonju College of Medicine, Wonju, Gangwon-Do 26426, Korea
Won Gil Cho: Mitohormesis Research Center, Yonsei University Wonju College of Medicine, Wonju, Gangwon-Do 26426, Korea
Yangsik Jeong: Mitohormesis Research Center, Yonsei University Wonju College of Medicine, Wonju, Gangwon-Do 26426, Korea
Hyun Kim: Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Gangwon-Do 26426, Korea
Kyu-Sang Park: Mitohormesis Research Center, Yonsei University Wonju College of Medicine, Wonju, Gangwon-Do 26426, Korea

IJERPH, 2020, vol. 17, issue 21, 1-9

Abstract: Hyperbaric oxygen therapy (HBOT) has been used to provide oxygen to underperfused organs following ischemia or carbon monoxide intoxication. Various beneficial consequences of HBOT have been reported, including wound healing, anti-inflammatory action, and cell survival; however, the molecular mechanisms underlying these effects have not been elucidated yet. We applied a single HBOT program consisting of administration of 2.8 atmospheres absolute (ATA) for 45 min, followed by 2.0 ATA for 55 min, to 10 male volunteers without any metabolic disease. Within 1 week of HBOT, there was no alteration in serum biochemical variables, except for an increase in triglyceride content. As a mitochondrial stress indicator, the serum concentration of growth differentiation factor 15 was reduced by HBOT. The circulating level of γ–glutamyltransferase was also decreased by HBOT, suggesting an attenuation of oxidative stress. HBOT increased adiponectin and reduced leptin levels in the serum, leading to an elevated adiponectin/leptin ratio. This is the first study to investigate the effect of HBOT on serum levels of metabolic stress-related biomarkers. We suggest that HBOT attenuates mitochondrial and oxidative stresses, and relieves metabolic burdens, indicating its potential for use in therapeutic applications to metabolic diseases.

Keywords: hyperbaric oxygen therapy; biomarker; mitochondria; oxidative stress (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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