Multiple Cryotherapy Attenuates Oxi-Inflammatory Response Following Skeletal Muscle Injury

Agnieszka Zembron-Lacny, Barbara Morawin, Edyta Wawrzyniak-Gramacka, Jaroslaw Gramacki, Pawel Jarmuzek, Dariusz Kotlega and Ewa Ziemann
Additional contact information
Agnieszka Zembron-Lacny: Department of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, 65-417 Zielona Gora, Poland
Barbara Morawin: Department of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, 65-417 Zielona Gora, Poland
Edyta Wawrzyniak-Gramacka: Department of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, 65-417 Zielona Gora, Poland
Jaroslaw Gramacki: Centre of Information Technologies, University of Zielona Gora, 65-417 Zielona Gora, Poland
Pawel Jarmuzek: Department of Nervous System Diseases, Collegium Medium University of Zielona Gora, Neurosurgery Center University Hospital in Zielona Gora, 65-417 Zielona Gora, Poland
Dariusz Kotlega: Department of Neurology, Pomeranian Medical University Szczecin, 70-204 Szczecin, Poland
Ewa Ziemann: Department of Sport Kinesiology, Poznan University of Physical Education, 61-871 Poznan, Poland

IJERPH, 2020, vol. 17, issue 21, 1-12

Abstract: The oxi-inflammatory response is part of the natural process mobilizing leukocytes and satellite cells that contribute to clearance and regeneration of damaged muscle tissue. In sports medicine, a number of post-injury recovery strategies, such as whole-body cryotherapy (WBC), are used to improve skeletal muscle regeneration often without scientific evidence of their benefits. The study was designed to assess the impact of WBC on circulating mediators of skeletal muscle regeneration. Twenty elite athletes were randomized to WBC group (3-min exposure to −120 °C, twice a day for 7 days) and control group. Blood samples were collected before the first WBC session and 1 day after the last cryotherapy exposure. WBC did not affect the indirect markers of muscle damage but significantly reduced the generation of reactive oxygen and nitrogen species (H 2 O 2 and NO) as well as the concentrations of serum interleukin 1β (IL-1β) and C-reactive protein (CRP). The changes in circulating growth factors, hepatocyte growth factor (HGF), insulin-like growth factor (IGF-1), platelet-derived growth factor (PDGF BB ), vascular endothelial growth factor (VEGF), and brain-derived neurotrophic factor (BDNF), were also reduced by WBC exposure. The study demonstrated that WBC attenuates the cascade of injury–repair–regeneration of skeletal muscles whereby it may delay skeletal muscle regeneration.

Keywords: cytokines; growth factors; hydrogen peroxide; nitric oxide; whole body cryotherapy (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/17/21/7855/pdf (application/pdf)
https://www.mdpi.com/1660-4601/17/21/7855/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:17:y:2020:i:21:p:7855-:d:435167

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().