Environmental Issues and Neurological Manifestations Associated with COVID-19 Pandemic: New Aspects of the Disease?

Luigi Bellocchio, Ioana Roxana Bordea, Andrea Ballini, Felice Lorusso, Denisa Hazballa, Ciro Gargiulo Isacco, Giuseppina Malcangi, Alessio Danilo Inchingolo, Gianna Dipalma, Francesco Inchingolo, Prisco Piscitelli, Giancarlo Logroscino and Alessandro Miani
Additional contact information
Luigi Bellocchio: INSERM, U1215 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, University of Bordeaux, 33000 Bordeaux, France
Ioana Roxana Bordea: Department of Oral Rehabilitation, Faculty of Dentistry, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
Andrea Ballini: Department of Biosciences, Biotechnologies and Biopharmaceutics, Campus Universitario “Ernesto Quagliariello” University of Bari “Aldo Moro”, 70125 Bari, Italy
Felice Lorusso: Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, 66100 Chieti, Italy
Denisa Hazballa: Kongresi Elbasanit, Rruga: Aqif Pasha, 3001 Elbasan, Albania
Ciro Gargiulo Isacco: Embryology and Regenerative Medicine and Immunology at Pham Chau Trinh University of Medicine Hoi An, Ho Chi Minh 70000, Vietnam
Giuseppina Malcangi: Department of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70121 Bari, Italy
Alessio Danilo Inchingolo: Department of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70121 Bari, Italy
Gianna Dipalma: Department of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70121 Bari, Italy
Francesco Inchingolo: Department of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70121 Bari, Italy
Prisco Piscitelli: Staff UNESCO Chair on Health Education and Sustainable Development, Federico II University, 80138 Naples, Italy
Giancarlo Logroscino: Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, 70121 Bari, Italy
Alessandro Miani: Department of Environmental Sciences and Policy, University of Milan, 20068 Milan, Italy

IJERPH, 2020, vol. 17, issue 21, 1-11

Abstract: Coronavirus (SARS-CoV-2) emerged in China in December 2019 and rapidly caused a global health pandemic. Current evidence seems to suggest a possible link with ecosystem disequilibrium and even air pollution. The primary manifestations affect respiratory and circulatory systems, but neurological features are also being reported through case reports and case series. We summarize neurological symptoms and complications associated with COVID-19. We have searched for original articles published in PubMed/Medline, PubMed Central and Google Scholar using the following keywords: “COVID-19”, “Coronavirus”, “pandemic”, “SARS-COV-2”, “neurology”, “neurological”, “complications” and “manifestations”. We found around 1000 publications addressing the issue of neurological conditions associated with COVID-19 infection. Amongst those, headache and dizziness are the most common reported symptoms followed by encephalopathy and delirium, while the most frequent complications are cerebrovascular accidents, Guillain–Barré syndrome, acute transverse myelitis, and acute encephalitis. Specific symptoms affecting the peripheral nervous system such as hyposmia and dysgeusia are the most common manifestations recorded in the selected studies. Interestingly, it was noted that these kinds of neurological symptoms might precede the typical features, such as fever and cough, in COVID patients. Neurological symptoms and complications associated with COVID-19 should be considered as a part of the clinical features of this novel global pandemic.

Keywords: neurological symptoms; environment; COVID-19; stroke; encephalitis; delirium (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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