Cohort Profile: ZOE 2.0—A Community-Based Genetic Epidemiologic Study of Early Childhood Oral Health

Kimon Divaris, Gary D. Slade, Andrea G. Ferreira Zandona, John S. Preisser, Jeannie Ginnis, Miguel A. Simancas-Pallares, Cary S. Agler, Poojan Shrestha, Deepti S. Karhade, Apoena de Aguiar Ribeiro, Hunyong Cho, Yu Gu, Beau D. Meyer, Ashwini R. Joshi, M. Andrea Azcarate-Peril, Patricia V. Basta, Di Wu and Kari E. North
Additional contact information
Kimon Divaris: Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina-Chapel Hill, NC 27599-7450, USA
Gary D. Slade: Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina-Chapel Hill, NC 27599-7450, USA
Andrea G. Ferreira Zandona: Department of Comprehensive Dentistry, School of Dental Medicine, Tufts University, Boston, MA 02111, USA
John S. Preisser: Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC 27599-7400, USA
Jeannie Ginnis: Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina-Chapel Hill, NC 27599-7450, USA
Miguel A. Simancas-Pallares: Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina-Chapel Hill, NC 27599-7450, USA
Cary S. Agler: Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina-Chapel Hill, NC 27599-7450, USA
Poojan Shrestha: Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina-Chapel Hill, NC 27599-7450, USA
Deepti S. Karhade: Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina-Chapel Hill, NC 27599-7450, USA
Apoena de Aguiar Ribeiro: Division of Diagnostic Sciences, Adams School of Dentistry, University of North Carolina-Chapel Hill, NC 27599-7450, USA
Hunyong Cho: Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC 27599-7400, USA
Yu Gu: Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC 27599-7400, USA
Beau D. Meyer: Division of Pediatric Dentistry, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA
Ashwini R. Joshi: Division of Surgery, School of Medicine, University of North Carolina-Chapel Hill, NC 27599-7050, USA
M. Andrea Azcarate-Peril: Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, and UNC Microbiome Core, Department of Medicine, School of Medicine, University of North Carolina-Chapel Hill, NC 27599-7555, USA
Patricia V. Basta: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC 27599-7400, USA
Di Wu: Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC 27599-7400, USA
Kari E. North: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC 27599-7400, USA

IJERPH, 2020, vol. 17, issue 21, 1-16

Abstract: Early childhood caries (ECC) is an aggressive form of dental caries occurring in the first five years of life. Despite its prevalence and consequences, little progress has been made in its prevention and even less is known about individuals’ susceptibility or genomic risk factors. The genome-wide association study (GWAS) of ECC (“ZOE 2.0”) is a community-based, multi-ethnic, cross-sectional, genetic epidemiologic study seeking to address this knowledge gap. This paper describes the study’s design, the cohort’s demographic profile, data domains, and key oral health outcomes. Between 2016 and 2019, the study enrolled 8059 3–5-year-old children attending public preschools in North Carolina, United States. Participants resided in 86 of the state’s 100 counties and racial/ethnic minorities predominated—for example, 48% ( n = 3872) were African American, 22% white, and 20% ( n = 1611) were Hispanic/Latino. Seventy-nine percent ( n = 6404) of participants underwent clinical dental examinations yielding ECC outcome measures—ECC (defined at the established caries lesion threshold) prevalence was 54% and the mean number of decayed, missing, filled surfaces due to caries was eight. Nearly all (98%) examined children provided sufficient DNA from saliva for genotyping. The cohort’s community-based nature and rich data offer excellent opportunities for addressing important clinical, epidemiologic, and biological questions in early childhood.

Keywords: children; early childhood caries; community-based studies; oral health; genomics (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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