Transmission and Long-Term Colonization Patterns of Staphylococcus aureus in a Nursing Home

Martyna Kasela, Agnieszka Grzegorczyk, Izabela Korona-Głowniak, Mateusz Ossowski, Bożena Nowakowicz-Dębek and Anna Malm
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Martyna Kasela: Department of Pharmaceutical Microbiology, Medical University of Lublin, 20-093 Lublin, Poland
Agnieszka Grzegorczyk: Department of Pharmaceutical Microbiology, Medical University of Lublin, 20-093 Lublin, Poland
Izabela Korona-Głowniak: Department of Pharmaceutical Microbiology, Medical University of Lublin, 20-093 Lublin, Poland
Mateusz Ossowski: Department of Animal Hygiene and Environmental Hazards, University of Life Sciences in Lublin, 20-950 Lublin, Poland
Bożena Nowakowicz-Dębek: Department of Animal Hygiene and Environmental Hazards, University of Life Sciences in Lublin, 20-950 Lublin, Poland
Anna Malm: Department of Pharmaceutical Microbiology, Medical University of Lublin, 20-093 Lublin, Poland

IJERPH, 2020, vol. 17, issue 21, 1-13

Abstract: Nursing homes might create an environment favorable for the transmission of Staphylococcus aureus because of the presence of hospitalized elderly, overcrowding and close contacts among people. We aimed at identifying risk factors for S. aureus colonization and determining the genetic relatedness of isolates demonstrating transmission among people. We investigated 736 swab samples from 92 residents and personnel for the presence of S. aureus . Swabs from anterior nares and throat were collected quarterly (2018) in a nursing home located in Poland. Genotyping was conducted using the multi-locus variable number of tandem repeats fingerprinting (MLVF) method. We observed high seasonal variation in the proportion of participants colonized with methicillin-resistant Staphylococcus aureus (MRSA) strains (0% to 13.5%). A multivariate analysis revealed that residents aged more than 85 years old are at risk for becoming intermittent S. aureus carriers ( p = 0.013). The MLVF analysis revealed a high genetic diversity among methicillin-sensitive S. aureus (MSSA) strains and close genetic relatedness between MRSA strains. We proved the advanced aged were predisposed to intermittent S. aureus carriage. Genotyping revealed the transmission of S. aureus among the participants living in a closed environment. A high genetic relatedness among isolated MRSA suggests its clonal spread in the nursing home.

Keywords: Staphylococcus aureus; transmission; nursing home (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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