Sleep Characteristics in Diabetic Patients Depending on the Occurrence of Neuropathic Pain and Related Factors

Cristina Naranjo, María Dueñas, Carlos Barrera, Guillermo Moratalla and Inmaculada Failde
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Cristina Naranjo: University Hospital Puerta del Mar, Avda. Ana de Viya 21, 1009 Cádiz, Spain
María Dueñas: Department of Statistics and Operational Research, University of Cadiz, Calle Enrique Villegas Vélez, 2, 11002 Cádiz, Spain
Carlos Barrera: University Hospital Puerta del Mar, Avda. Ana de Viya 21, 1009 Cádiz, Spain
Guillermo Moratalla: Primary Care Center Loreto-Puntales, Health district Bahía de Cádiz-La Janda, C/ Hidroavión Numancia 0, 11011 Cádiz, Spain
Inmaculada Failde: Biomedical Research and Innovation Institute of Cádiz (INiBICA), Avda. Ana de Viya 21, 11009 Cádiz, Spain

IJERPH, 2020, vol. 17, issue 21, 1-13

Abstract: This study aims to compare the sleep characteristics (structure and quality) in patients with type-2 diabetes mellitus with and without diabetic neuropathic pain (DNP), and to investigate the relationship of sensory phenotypes, anxiety, and depression with sleep quality in DNP patients. A cross-sectional study was performed in patients with type-2 diabetes mellitus and neuropathy. Patients were classified into two groups—with or without neuropathic pain—according to the “Douleur Neuropathique-4 (DN4)” scale. Sleep characteristics and quality (Medical Outcomes Study—MOS-sleep), pain phenotype (Neuropathic Pain Symptom Inventory—NPSI), mood status (Hospital Anxiety and Depression scale—HADS), pain intensity (Visual Analogue Scale—VAS), and quality of life (SF-12v2) were measured. The sample included 130 patients (65 with DNP). The mean scores in all the dimensions of the MOS-sleep scale were higher (more disturbances) in the DNP patients. Higher scores in anxiety or depression, greater intensity of pain or a higher score in the paroxysmal pain phenotype were associated with lower sleep quality in DNP patients. A shorter duration of the diabetes and lower levels of glycated hemoglobin were also associated with lower sleep quality. The results show the relationship between DNP and sleep quality, and the importance of assessing sensory phenotypes and mental comorbidities in these patients. Taking these factors into consideration, to adopt a multimodal approach is necessary to achieve better clinical results.

Keywords: diabetes mellitus type 2; diabetes neuropathic pain; sleep disorders; sensorial phenotype; anxiety; depression (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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Citations: View citations in EconPapers (2)

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