Dual-Task Tests Predict Conversion to Dementia—A Prospective Memory-Clinic-Based Cohort Study

Hanna B Åhman, Lars Berglund, Ylva Cedervall, Lena Kilander, Vilmantas Giedraitis, Kevin J. McKee, Martin Ingelsson, Erik Rosendahl and Anna Cristina Åberg
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Hanna B Åhman: Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, SE-751 22 Uppsala, Sweden
Lars Berglund: Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, SE-751 22 Uppsala, Sweden
Ylva Cedervall: Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, SE-751 22 Uppsala, Sweden
Lena Kilander: Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, SE-751 22 Uppsala, Sweden
Vilmantas Giedraitis: Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, SE-751 22 Uppsala, Sweden
Kevin J. McKee: School of Education, Health and Social Studies, Dalarna University, SE-791 88 Falun, Sweden
Martin Ingelsson: Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, SE-751 22 Uppsala, Sweden
Erik Rosendahl: Department of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, SE-901 87 Umeå, Sweden
Anna Cristina Åberg: Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, SE-751 22 Uppsala, Sweden

IJERPH, 2020, vol. 17, issue 21, 1-14

Abstract: The aim of this study was to investigate whether Timed Up-and-Go (TUG) dual-task (TUGdt) tests predict dementia incidence among patients with subjective or mild cognitive impairment (SCI; MCI). Other study objectives were to determine whether TUGdt improves dementia prediction compared to a) demographic characteristics and standard cognitive tests alone; and b) TUG and Verbal Fluency performed separately. Patients ( n = 172, age range 39–91 years, 78 women) with SCI or MCI performed TUGdt tests, including 1) naming animals and 2) reciting months backwards, and clinical cognitive tests at baseline. Diagnoses were identified at follow-up after 2.5 years. Logistic regression was used to predict dementia incidence, receiver operating characteristic (ROC) curves and c-statistics for predictive capacity. Analyses were stratified by age and gender. At follow-up, 51 patients had developed dementia. The TUGdt result “animals/10 s” was associated with dementia incidence (standardized odds ratio (OR) = 4.06, 95% confidence interval (CI) 2.28–7.23, p < 0.001), more so among patients under the median age of 72 years (standardized OR = 19.4, 95% CI 3.53–106.17, p < 0.001). TUGdt “animals/10 s” improved dementia prediction compared to demographic characteristics and standard tests alone (c-statistics 0.88 to 0.94) and single-task tests (c-statistics 0.86 to 0.89), but only in the younger patient group. TUGdt has the potential to become a useful tool for dementia prediction.

Keywords: dual-task; dementia; mild cognitive impairment; subjective cognitive impairment; gait (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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