Associations between Levels of Urinary Oxidative Stress of 8-OHdG and Risk of Atopic Diseases in Children

Pang-Yen Chen, Chien-Wei Chen, Yu-Jang Su, Wen-Han Chang, Wei-Fong Kao, Chen-Chang Yang and I-Jen Wang
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Pang-Yen Chen: Department of Emergency Medicine, Mackay Memorial Hospital, Taipei 10449, Taiwan
Chien-Wei Chen: Department of Diagnostic Radiology, Chang Gung Memorial Hospital Chiayi Branch, Chiayi 613, Taiwan
Yu-Jang Su: Department of Emergency Medicine, Mackay Memorial Hospital, Taipei 10449, Taiwan
Wen-Han Chang: Department of Emergency Medicine, Mackay Memorial Hospital, Taipei 10449, Taiwan
Wei-Fong Kao: Department of Emergency Medicine, School of Medicine, Taipei Medical University, Taipei 110, Taiwan
Chen-Chang Yang: Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan
I-Jen Wang: Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan

IJERPH, 2020, vol. 17, issue 21, 1-13

Abstract: The oxidative stress biomarker of urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) was reported to be changed in patients with allergic diseases. Measurement of urinary oxidative products is noninvasive. However, correlations between the severity levels of atopic diseases and oxidative stress remain unclear. This study aimed to investigate the association among urinary 8-OHdG, atopic dermatitis (AD), and the phenotypes of atopic diseases in children. In a nested case-control study, participants of kindergarten children were enrolled from the Childhood Environment and Allergic Diseases Study (CEAS). Urinary analyses and urinary 8-OHdG were performed on samples from 200 children with AD as cases and 200 age- and sex-matched controls. Our study presents the following main findings: (1) The urinary 8-OHdG levels were significantly higher in cases than controls. Higher urinary 8-OHdG levels were associated with the risk of AD in a dose-response-manner; (2) Children’s AD history was associated with higher risks of asthma, allergic rhinitis, and night pruritus; (3) For children with AD, urinary 8-OHdG levels of >75th percentile were associated with higher risk of asthma, compared with the reference group of 0–25th percentiles. In summary, this study provides better understanding of the underlying mechanisms of AD and urinary 8-OHdG by analyzing a large-scale sample survey in Taiwan.

Keywords: asthma; atopic dermatitis; atopic diseases; oxidative stress; urinary 8-OhdG (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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