Relationship between Bell’s Palsy and Previous Statin Use: A Case/Non-Case Study

So Young Kim, Jee Hye Wee, Chanyang Min, Dae-Myoung Yoo and Hyo Geun Choi
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So Young Kim: Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea
Jee Hye Wee: Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, 22, Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang-si, Gyeonggi-do, Anyang 14068, Korea
Chanyang Min: Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea
Dae-Myoung Yoo: Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea
Hyo Geun Choi: Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, 22, Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang-si, Gyeonggi-do, Anyang 14068, Korea

IJERPH, 2020, vol. 17, issue 22, 1-10

Abstract: We intended to determine the relationship between previous statin use and Bell’s palsy in a large study population receiving statins for the past 2 years. The Korean National Health Insurance Service—Health Screening Cohort data from 2002 to 2015 were collected. Participants with Bell’s palsy ( n = 3203) were matched with participants without Bell’s palsy ( n = 12,812). The number of days of previous statin use for 2 years before the onset of Bell’s palsy was analyzed using conditional logistic regression. Subgroups of age, sex, obesity, smoking, alcohol consumption, total cholesterol, and blood pressure were analyzed for any association between Bell’s palsy and prior statin use. The Bell’s palsy group reported greater statin use than the non-Bell’s palsy group (84.6 (standard deviation, SD = 201.7) vs. 74.4(SD = 189.4), p = 0.009). Previous statin use was associated with Bell’s palsy in the crude model (95% confidence intervals = 1.03–1.19, p = 0.006). However, this relationship disappeared when the possible covariates were adjusted for in model 2. All subgroups showed no increased odds for Bell’s palsy in previous statin users. We did not find an association between Bell’s palsy and previous statin use in this Korean population aged ≥40 years.

Keywords: Bell’s palsy; hydroxymethylglutaryl-CoA reductase inhibitor; cohort study; case/non-case Bell’s palsy study (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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