Quality of Life in a Cohort of 1078 Women Diagnosed with Breast Cancer in Spain: 7-Year Follow-Up Results in the MCC-Spain Study

Jéssica Alonso-Molero, Trinidad Dierssen-Sotos, Ines Gomez-Acebo, Nerea Fernandez de Larrea Baz, Marcela Guevara, Pilar Amiano, Gemma Castaño-Vinyals, Tania Fernandez-Villa, Victor Moreno, Juan Bayo, Ana Molina-Barceloa, María Fernández-Ortíz, Claudia Suarez-Calleja, Rafael Marcos-Gragera, Xavier Castells, Leire Gil-Majuelo, Eva Ardanaz, Beatriz Pérez-Gómez, Manolis Kogevinas, Marina Pollán and Javier Llorca
Additional contact information
Jéssica Alonso-Molero: Department of Preventive Medicine and Public Health, University of Cantabria—IDIVAL, 39011 Santander, Spain
Trinidad Dierssen-Sotos: Department of Preventive Medicine and Public Health, University of Cantabria—IDIVAL, 39011 Santander, Spain
Ines Gomez-Acebo: Department of Preventive Medicine and Public Health, University of Cantabria—IDIVAL, 39011 Santander, Spain
Nerea Fernandez de Larrea Baz: CIBER Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain
Marcela Guevara: CIBER Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain
Pilar Amiano: CIBER Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain
Gemma Castaño-Vinyals: CIBER Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain
Tania Fernandez-Villa: Grupo de Investigación en Interacciones Gen-Ambiente y Salud (GIIGAS), Instituto de Biomedicina (IBIOMED), Universidad de León, 24071 León, Spain
Victor Moreno: CIBER Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain
Juan Bayo: Servicio de Oncología del Hospital Universitario Juan Ramón Jiménez, 21005 Huelva, Spain
Ana Molina-Barceloa: Cancer and Public Health Area, FISABIO—Public Health, 46035 Valencia, Spain
María Fernández-Ortíz: Department of Preventive Medicine and Public Health, University of Cantabria—IDIVAL, 39011 Santander, Spain
Claudia Suarez-Calleja: Área de Medicina Preventiva, Departamento de Medicina, Universidad de Oviedo, 33006 Asturias, Spain
Rafael Marcos-Gragera: CIBER Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain
Xavier Castells: Epidemiology and Evaluation Department, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain
Leire Gil-Majuelo: Public Health Division of Gipuzkoa, Biodonostia Research Institute, 20014 San Sebastian, Spain
Eva Ardanaz: CIBER Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain
Beatriz Pérez-Gómez: CIBER Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain
Manolis Kogevinas: CIBER Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain
Marina Pollán: CIBER Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain
Javier Llorca: CIBER Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain

IJERPH, 2020, vol. 17, issue 22, 1-16

Abstract: Breast cancer is the most frequent cause of tumors and net survival is increasing. Achieving a higher survival probability reinforces the importance of studying health-related quality of life (HR-QoL). The main aim of this work is to test the relationship between different sociodemographic, clinical and tumor-intrinsic characteristics, and treatment received with HR-QoL measured using SF-12 and the FACT/NCCN (National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy) Breast Symptom Index (FBSI). Women with breast cancer recruited between 2008 and 2013 and followed-up until 2017–2018 in a prospective cohort answered two HR-QoL surveys: the SF-12 and FBSI. The scores obtained were related to woman and tumor characteristics using linear regression models. The telephone survey was answered by 1078 women out of 1685 with medical record follow-up (64%). Increases in all three HR-QoL scores were associated with higher educational level. The score differences between women with university qualifications and women with no schooling were 5.43 for PCS-12, 6.13 for MCS-12 and 4.29 for FBSI. Histological grade at diagnosis and recurrence in the follow-up displayed a significant association with mental and physical HR-QoL, respectively. First-line treatment received was not associated with HR-QoL scores. On the other hand, most tumor characteristics were not associated with HR-QoL. As breast cancer survival is improving, further studies are needed to ascertain if these differences still hold in the long run.

Keywords: quality of life; breast cancer; SF-12; FBSI; educational level (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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