Cardiorespiratory Fitness Mediates Cognitive Performance in Chronic Heart Failure Patients and Heart Transplant Recipients

Florent Besnier, Béatrice Bérubé, Christine Gagnon, Miloudza Olmand, Paula Aver Bretanha Ribeiro, Anil Nigam, Martin Juneau, Lucie Blondeau, Michel White, Vincent Gremeaux, Louis Bherer and Mathieu Gayda
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Florent Besnier: Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada
Béatrice Bérubé: Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada
Christine Gagnon: Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada
Miloudza Olmand: Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada
Paula Aver Bretanha Ribeiro: Research Centre, University of Montreal Hospital Research Centre, Montreal, QC H2X 0A9, Canada
Anil Nigam: Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada
Martin Juneau: Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada
Lucie Blondeau: Montreal Health Innovations Coordinating Center, Montreal Heart Institute, Montreal, QC H1T 1C8, Canada
Michel White: Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada
Vincent Gremeaux: Sport Medicine Unit, Division of Physical Medicine and Rehabilitation, Swiss Olympic Medical Center, Lausanne University Hospital, 1011 Lausanne, Switzerland
Louis Bherer: Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada
Mathieu Gayda: Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada

IJERPH, 2020, vol. 17, issue 22, 1-14

Abstract: We compared cognitive profiles in chronic heart failure patients (HF), heart transplant recipients (HT) and healthy controls (HC) and examined the relationship between cardiorespiratory fitness ( V ? O 2peak ), peak cardiac output (CO peak ) and cognitive performance. Stable HT patients ( n = 11), HF patients ( n = 11) and HC ( n = 13) (61.5 ± 8.5 years) were recruited. Four cognitive composite scores targeting different cognitive functions were computed from neuropsychological tests: working memory, processing speed, executive functions and verbal memory. Processing speed and executive function scores were higher, which indicates lower performances in HF and HT compared to HC ( p < 0.05). V ? O 2peak and first ventilatory threshold (VT 1 ) were lower in HF and HT vs. HC ( p < 0.01). CO peak was lower in HF vs. HT and HC ( p < 0.01). Processing speed, executive function and verbal memory performances were correlated with V ? O 2peak , VT 1 and peak cardiac hemodynamics ( p < 0.05). Mediation analyses showed that V ? O 2peak and VT 1 mediated the relationship between group and processing speed and executive function performances in HF and HT. CO peak fully mediated executive function and processing speed performances in HF only. V ? O 2peak and CO peak were related to cognitive performance in the entire sample. In addition, V ? O 2peak and VT 1 fully mediated the relationship between group and executive function and processing speed performances.

Keywords: heart failure; heart transplant; cardiorespiratory fitness; cognition (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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