Surgical Treatment of Medication-Related Osteonecrosis of the Jaw: A Retrospective Study

Na Rae Choi, Jung Han Lee, Jin Young Park and Dae Seok Hwang
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Na Rae Choi: Department of Oral Maxillofacial Surgery, School of Dentistry, Pusan National University, Yangsan 50612, Korea
Jung Han Lee: Department of Oral Maxillofacial Surgery, School of Dentistry, Pusan National University, Yangsan 50612, Korea
Jin Young Park: Department of Oral Maxillofacial Surgery, School of Dentistry, Pusan National University, Yangsan 50612, Korea
Dae Seok Hwang: Department of Oral Maxillofacial Surgery, School of Dentistry, Pusan National University, Yangsan 50612, Korea

IJERPH, 2020, vol. 17, issue 23, 1-9

Abstract: The purpose of this study was to confirm the success rate of surgical treatment of medication-related osteonecrosis of the jaw (MRONJ) in patients at a single institution (Association of Oral and Maxillofacial Surgery (AAOMS) stages 1, 2, or 3), and to identify the factors that influence treatment outcomes. As a result of analyzing the outcomes of treatment, surgical “success” was achieved in 93.97% (109) of cases, and “failure” was observed at 6.03% (7) cases. Analysis of patient factors that potentially affect treatment outcomes showed that zoledronate dose ( p = 0.005) and the IV (intravenous) injection of drugs ( p = 0.044) had significant negative impacts.

Keywords: MRONJ; bisphosphonate; osteoporosis; surgical treatment (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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