Serum Gamma Glutamyltransferase Is Associated with 25-Hydroxyvitamin D Status in Elderly Patients with Stable Coronary Artery Disease

Aleksander Danikiewicz, Bartosz Hudzik, Justyna Nowak, Joanna Kowalska, Iwona Zieleń-Zynek, Janusz Szkodzinski, Han Naung Tun and Barbara Zubelewicz-Szkodzinska
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Aleksander Danikiewicz: Department of Nutrition Related Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia, 41-900 Bytom, Poland
Bartosz Hudzik: Department of Cardiovascular Disease Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia, 41-900 Bytom, Poland
Justyna Nowak: Department of Cardiovascular Disease Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia, 41-900 Bytom, Poland
Joanna Kowalska: Department of Nutrition Related Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia, 41-900 Bytom, Poland
Iwona Zieleń-Zynek: Department of Nutrition Related Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia, 41-900 Bytom, Poland
Janusz Szkodzinski: Third Department of Cardiology, Silesian Center for Heart Disease, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-800 Zabrze, Poland
Han Naung Tun: Research and Clinical Working Groups, European Society of Cardiology, 06-903 Sophia Antipolis, France
Barbara Zubelewicz-Szkodzinska: Department of Nutrition Related Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia, 41-900 Bytom, Poland

IJERPH, 2020, vol. 17, issue 23, 1-12

Abstract: Background: No previous study has investigated the association between gamma glutamyltransferase (GGT) and vitamin D in patients with stable coronary artery disease (CAD). We investigated the cross-sectional associations between vitamin D status as assessed by serum 25(OH)D and GGT. Methods: 169 patients were enrolled. Study population was divided into three groups: 1: 25(OH)D < 10 ng/mL ( n = 59); 2: 25(OH)D 10–20 ng/mL ( n = 82), and 3: 25(OH)D > 20 ng/mL ( n = 28). Based on a cut-off GGT value identified in ROC analysis, we also divided the study population to compare the following groups: GGT ≤19 ( n = 66) and GGT >19 ( n = 103). Results: GGT activity was the highest in vitamin D severely deficient patients and the lowest in vitamin D insufficient patients. GGT was inversely correlated with 25(OH)D concentrations (R = −0.23; p = 0.002). The receiver operating characteristics curve identified the discrimination threshold of GGT of >19 U/L in predicting vitamin D deficiency. Higher leukocyte and neutrophil counts and lower 25(OH)D concentration were found in patients with GGT > 19 U/L. Conclusions: We identified an interaction between declining 25(OH)D levels and rising GGT levels with increasing age, which resulted in an unfavorable 25(OH)D-to-GGT ratio in stable CAD patients. These results suggest that these changes might further contribute to a high cardiovascular risk in the elderly.

Keywords: gamma glutamyltransferase; vitamin D; 25(OH)D; coronary artery disease (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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